LETHE: A Digital Intervention for Cognitive Decline

Vasileios S. Loukas; Thomas Kassiotis; Ignacio Lamata Martinez; Lefteris Koumakis; Jeroen Bruinsma; Roberto Pasciuti; Monica Balatresi; Ville Tenhunen; Adam Fiakkas; Lelia Ataliani; Georgia S. Karanasiou; Manolis Tsiknakis; Hannes Hilberger; Markus Bodenler; Bianca Schnalzer; Simone Huber; Mattia Pirani; Matteo Colombo; Sten Hanke; Dimitrios I. Fotiadis

doi:10.1109/EMBC40787.2023.10340897

LETHE: A Digital Intervention for Cognitive Decline

Vasileios S. Loukas^*, Thomas Kassiotis, Ignacio Lamata Martinez, Lefteris Koumakis, Jeroen Bruinsma, Roberto Pasciuti, Monica Balatresi, Ville Tenhunen, Adam Fiakkas, Lelia Ataliani, Georgia S. Karanasiou, Manolis Tsiknakis, Hannes Hilberger, Markus Bodenler, Bianca Schnalzer, Simone Huber, Mattia Pirani, Matteo Colombo, Sten Hanke, Dimitrios I. Fotiadis

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

Abstract

Dementia is the main cause of disability in elderly populations. It has been shown that the risk factors of dementia are a mixture of pathological, lifestyle and heritable factors, with some of those being provably modifiable. Early diagnosis of dementia and approaches to slow down its evolution are currently the most prominent management methodologies due to lack of a cure. For that reason, a plethora of home-based assistive technologies for dementia management do exist, with most of them focusing on the improvement of memory and thinking. The main objective of LETHE is prevention in the whole spectrum of cognitive decline in the elderly population at risk reaching from asymptomatic to subjective or mild cognitive impairment to prodromal Dementia. LETHE will provide a Big Data collection platform and analysis system, that will allow prevention, personalized risk detection and intervention on cognitive decline. Through the subsequent 2-year clinical trial, the LETHE system, as well as the respective knowledge gained will be evaluated and validated. The scope of the current paper is to introduce the LETHE study and its respective novel platform as a holistic approach to multidomain lifestyle intervention trial studies. The present work depicts the architectural perspective and extends beyond state-of-the-art guidelines and approaches to health management systems and cloud platform development.Clinical Relevance-Patient Management Systems as well as lifestyle management platforms have significant clinical relevance as they allow for remote and continuous monitoring of patients' health status. LETHE aims to improve patient outcomes by providing predictive models for cognitive decline and patient adherence to the multimodal lifestyle intervention, enabling prompt and appropriate medical decisions.

Original language	English
Title of host publication	2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings
Place of Publication	Sydney
Publisher	IEEE
Number of pages	4
ISBN (Electronic)	9798350324471
DOIs	https://doi.org/10.1109/EMBC40787.2023.10340897
Publication status	Published - 1 Jan 2023
Event	45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference - Sydney, Australia Duration: 24 Jul 2023 → 27 Jul 2023 https://embc.embs.org/2023/

Publication series

Series	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN	1557-170X

Conference

Conference	45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference
Abbreviated title	IEEE EMBC 2023
Country/Territory	Australia
City	Sydney
Period	24/07/23 → 27/07/23
Internet address	https://embc.embs.org/2023/

Access to Document

10.1109/EMBC40787.2023.10340897

Cite this

Loukas, V. S., Kassiotis, T., Martinez, I. L., Koumakis, L., Bruinsma, J., Pasciuti, R., Balatresi, M., Tenhunen, V., Fiakkas, A., Ataliani, L., Karanasiou, G. S., Tsiknakis, M., Hilberger, H., Bodenler, M., Schnalzer, B., Huber, S., Pirani, M., Colombo, M., Hanke, S., & Fotiadis, D. I. (2023). LETHE: A Digital Intervention for Cognitive Decline. In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings IEEE. https://doi.org/10.1109/EMBC40787.2023.10340897

Loukas, Vasileios S. ; Kassiotis, Thomas ; Martinez, Ignacio Lamata et al. / LETHE : A Digital Intervention for Cognitive Decline. 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. Sydney : IEEE, 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{37fd90b3dbc44fe7ab5557d003b11dfd,

title = "LETHE: A Digital Intervention for Cognitive Decline",

abstract = "Dementia is the main cause of disability in elderly populations. It has been shown that the risk factors of dementia are a mixture of pathological, lifestyle and heritable factors, with some of those being provably modifiable. Early diagnosis of dementia and approaches to slow down its evolution are currently the most prominent management methodologies due to lack of a cure. For that reason, a plethora of home-based assistive technologies for dementia management do exist, with most of them focusing on the improvement of memory and thinking. The main objective of LETHE is prevention in the whole spectrum of cognitive decline in the elderly population at risk reaching from asymptomatic to subjective or mild cognitive impairment to prodromal Dementia. LETHE will provide a Big Data collection platform and analysis system, that will allow prevention, personalized risk detection and intervention on cognitive decline. Through the subsequent 2-year clinical trial, the LETHE system, as well as the respective knowledge gained will be evaluated and validated. The scope of the current paper is to introduce the LETHE study and its respective novel platform as a holistic approach to multidomain lifestyle intervention trial studies. The present work depicts the architectural perspective and extends beyond state-of-the-art guidelines and approaches to health management systems and cloud platform development.Clinical Relevance-Patient Management Systems as well as lifestyle management platforms have significant clinical relevance as they allow for remote and continuous monitoring of patients' health status. LETHE aims to improve patient outcomes by providing predictive models for cognitive decline and patient adherence to the multimodal lifestyle intervention, enabling prompt and appropriate medical decisions.",

author = "Loukas, {Vasileios S.} and Thomas Kassiotis and Martinez, {Ignacio Lamata} and Lefteris Koumakis and Jeroen Bruinsma and Roberto Pasciuti and Monica Balatresi and Ville Tenhunen and Adam Fiakkas and Lelia Ataliani and Karanasiou, {Georgia S.} and Manolis Tsiknakis and Hannes Hilberger and Markus Bodenler and Bianca Schnalzer and Simone Huber and Mattia Pirani and Matteo Colombo and Sten Hanke and Fotiadis, {Dimitrios I.}",

note = "Funding Information: * Research supported by the LETHE project, which has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under grant agreement No. 101017405. Publisher Copyright: {\textcopyright} 2023 IEEE.; 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, IEEE EMBC 2023 ; Conference date: 24-07-2023 Through 27-07-2023",

year = "2023",

month = jan,

day = "1",

doi = "10.1109/EMBC40787.2023.10340897",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "IEEE",

booktitle = "2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings",

address = "United States",

url = "https://embc.embs.org/2023/",

}

Loukas, VS, Kassiotis, T, Martinez, IL, Koumakis, L, Bruinsma, J, Pasciuti, R, Balatresi, M, Tenhunen, V, Fiakkas, A, Ataliani, L, Karanasiou, GS, Tsiknakis, M, Hilberger, H, Bodenler, M, Schnalzer, B, Huber, S, Pirani, M, Colombo, M, Hanke, S & Fotiadis, DI 2023, LETHE: A Digital Intervention for Cognitive Decline. in 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. IEEE, Sydney, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, Sydney, New South Wales, Australia, 24/07/23. https://doi.org/10.1109/EMBC40787.2023.10340897

LETHE: A Digital Intervention for Cognitive Decline. / Loukas, Vasileios S.; Kassiotis, Thomas; Martinez, Ignacio Lamata et al.
2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. Sydney: IEEE, 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - LETHE

T2 - 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference

AU - Loukas, Vasileios S.

AU - Kassiotis, Thomas

AU - Martinez, Ignacio Lamata

AU - Koumakis, Lefteris

AU - Bruinsma, Jeroen

AU - Pasciuti, Roberto

AU - Balatresi, Monica

AU - Tenhunen, Ville

AU - Fiakkas, Adam

AU - Ataliani, Lelia

AU - Karanasiou, Georgia S.

AU - Tsiknakis, Manolis

AU - Hilberger, Hannes

AU - Bodenler, Markus

AU - Schnalzer, Bianca

AU - Huber, Simone

AU - Pirani, Mattia

AU - Colombo, Matteo

AU - Hanke, Sten

AU - Fotiadis, Dimitrios I.

N1 - Funding Information: * Research supported by the LETHE project, which has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 101017405. Publisher Copyright: © 2023 IEEE.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Dementia is the main cause of disability in elderly populations. It has been shown that the risk factors of dementia are a mixture of pathological, lifestyle and heritable factors, with some of those being provably modifiable. Early diagnosis of dementia and approaches to slow down its evolution are currently the most prominent management methodologies due to lack of a cure. For that reason, a plethora of home-based assistive technologies for dementia management do exist, with most of them focusing on the improvement of memory and thinking. The main objective of LETHE is prevention in the whole spectrum of cognitive decline in the elderly population at risk reaching from asymptomatic to subjective or mild cognitive impairment to prodromal Dementia. LETHE will provide a Big Data collection platform and analysis system, that will allow prevention, personalized risk detection and intervention on cognitive decline. Through the subsequent 2-year clinical trial, the LETHE system, as well as the respective knowledge gained will be evaluated and validated. The scope of the current paper is to introduce the LETHE study and its respective novel platform as a holistic approach to multidomain lifestyle intervention trial studies. The present work depicts the architectural perspective and extends beyond state-of-the-art guidelines and approaches to health management systems and cloud platform development.Clinical Relevance-Patient Management Systems as well as lifestyle management platforms have significant clinical relevance as they allow for remote and continuous monitoring of patients' health status. LETHE aims to improve patient outcomes by providing predictive models for cognitive decline and patient adherence to the multimodal lifestyle intervention, enabling prompt and appropriate medical decisions.

AB - Dementia is the main cause of disability in elderly populations. It has been shown that the risk factors of dementia are a mixture of pathological, lifestyle and heritable factors, with some of those being provably modifiable. Early diagnosis of dementia and approaches to slow down its evolution are currently the most prominent management methodologies due to lack of a cure. For that reason, a plethora of home-based assistive technologies for dementia management do exist, with most of them focusing on the improvement of memory and thinking. The main objective of LETHE is prevention in the whole spectrum of cognitive decline in the elderly population at risk reaching from asymptomatic to subjective or mild cognitive impairment to prodromal Dementia. LETHE will provide a Big Data collection platform and analysis system, that will allow prevention, personalized risk detection and intervention on cognitive decline. Through the subsequent 2-year clinical trial, the LETHE system, as well as the respective knowledge gained will be evaluated and validated. The scope of the current paper is to introduce the LETHE study and its respective novel platform as a holistic approach to multidomain lifestyle intervention trial studies. The present work depicts the architectural perspective and extends beyond state-of-the-art guidelines and approaches to health management systems and cloud platform development.Clinical Relevance-Patient Management Systems as well as lifestyle management platforms have significant clinical relevance as they allow for remote and continuous monitoring of patients' health status. LETHE aims to improve patient outcomes by providing predictive models for cognitive decline and patient adherence to the multimodal lifestyle intervention, enabling prompt and appropriate medical decisions.

U2 - 10.1109/EMBC40787.2023.10340897

DO - 10.1109/EMBC40787.2023.10340897

M3 - Conference article in proceeding

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

BT - 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings

PB - IEEE

CY - Sydney

Y2 - 24 July 2023 through 27 July 2023

ER -

Loukas VS, Kassiotis T, Martinez IL, Koumakis L, Bruinsma J, Pasciuti R et al. LETHE: A Digital Intervention for Cognitive Decline. In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. Sydney: IEEE. 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC40787.2023.10340897