Left ventricular volume and wall stress are linked to lung function impairment in COPD

Peter Alter*, Rudolf A. Jorres*, Henrik Watz, Tobias Welte, Sven Glaser, Holger Schulz, Robert Bals, Annika Karch, Emiel F. M. Wouters, Jorgen Vestbo, David Young, Claus F. Vogelmeier

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)


Background: Cardiovascular comorbidities are common in chronic obstructive pulmonary disease (COPD). We examined the association between airflow limitation, hyperinflation and the left ventricle (LV). Methods: Patients from the COPD cohort COSYCONET underwent evaluations including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), effective airway resistance (Reff), intrathoracic gas volume (ITGV), and echocardiographic LV end-diastolic volume (LVEDV), stroke volume (LVSV), end-systolic volume (LVESV), and end-diastolic and end-systolic LV wall stress. Data from Visit 1 (baseline) and Visit 3 (18 months later) were used. In addition to comparisons of both visits, multivariate regression analysis was conducted, followed by structural equation modelling (SEM) with latent variables "Lung' and "Left heart. Results: A total of 641 participants were included in this analysis. From Visit 1 to Visit 3, there were significant declines in FEV1 and FEV1/FVC, and increases in R-eff, ITGV and LV end-diastolic wall stress, and a borderline significant decrease in LV mass. There were significant correlations of: FEV1 predicted with LVEDV and LVSV; R-eff (with LVSV; and ITGV with LV mass and LV end-diastolic wall stress. The SEM fitted the data of both visits well (comparative fit index: 0.978, 0.962), with strong correlation between "Lung" and "Left heart". Conclusions: We demonstrated a relationship between lung function impairment and LV wall stress in patients with COPD. This supports the hypothesis that LV impairment in COPD could be initiated or promoted, at least partly, by mechanical factors exerted by the lung disorder. (C) 2018 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalInternational Journal of Cardiology
Publication statusPublished - 15 Jun 2018


  • COPD
  • Airflow limitation
  • Hyperinflation
  • Heart failure
  • Ventricular wall stress
  • Dyspnea
  • Breathing
  • RISK

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