Large variation in the utilization of liver resections in stage IV colorectal cancer patients with metastases confined to the liver

J. 't Lam-Boer*, C. Al Ali, R. H. A. Verhoeven, R. M. H. Roumen, V. E. P. P. Lemmen, A. M. Rijken, J. H. W. De Wilt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)

Abstract

Surgical resection of both the primary tumor and all metastases is considered the only chance of cure for patients with stage IV colorectal cancer. The aim of this study was to investigate change over time in the utilization of liver resections, as well as possible institutional variations.All patients diagnosed with stage IV colorectal cancer with metastases confined to the liver (n = 1617) between 2004 and 2012 were selected from the population-based Eindhoven Cancer Registry. The proportion of patients undergoing liver resection was investigated. Institutional variation in the period 2010-2012 was analyzed using logistic regression. Kaplan-Meier and Cox regression analyses were used to analyze overall survival.The proportion of patients undergoing liver metastasectomy increased over time from 8% in 2004 to approximately 24% in 2012. There was a wide inter-hospital variation in the proportion of patients that underwent a liver resection (range: 14-34%) in the period 2010-2012. Liver resection was more often performed in younger patients and in rectal cancer patients. Median overall survival in patients undergoing liver resection was 55 months. Adjusted for potential confounders, resection of liver metastases was strongly associated with improved overall survival (HR 0.32, 95%CI 0.25-0.40).This study shows that despite the excellent long-term prognosis for patients with stage IV colorectal cancer after liver resection, there is still a large institutional variation in the utilization of this potentially curative therapy.
Original languageEnglish
Pages (from-to)1217-1225
JournalEuropean Journal of Surgical Oncology
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 2015

Keywords

  • Colorectal cancer
  • Metastases
  • Stage IV
  • Liver resection
  • Metastasectomy
  • Variation

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