Abstract
The leucocyte expressed surface-bound L-selectin belongs to the selectin family of adhesion molecules. It exhibits adhesive as well as signalling functions. Mainly, it is of importance in lymphocyte homing and in the extravasation of leucocytes into the surrounding tissue during inflammation. Acting in the initial step of the cell adhesion cascade, L-selectin is responsible for the rolling of leucocytes on endothelial layers. Therefore, L-selectin is thought to be an adequate target for pharmacological interventions. Beneath the discussion of the molecules' general features like molecule structure and its regulation, the review focuses firstly on L-selectin in the context of posttraumatic inflammatory disorders, and secondly on the importance of L-selectin specific signalling events.
Original language | English |
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Pages (from-to) | 39-52 |
Number of pages | 14 |
Journal | Experimental and Toxicologic Pathology |
Volume | 57 |
Issue number | 1 |
DOIs | |
Publication status | Published - Aug 2005 |
Externally published | Yes |
Keywords
- L-selectin
- adhesion
- signal transduction
- trauma
- sepsis
- SOLUBLE L-SELECTIN
- TUMOR-NECROSIS-FACTOR
- NODE HOMING RECEPTOR
- LEUKOCYTE L-SELECTIN
- SIALYL-LEWIS-X
- ATTENUATES NEUTROPHIL ACCUMULATION
- MYOCARDIAL REPERFUSION INJURY
- MEMBRANE-PROXIMAL CLEAVAGE
- TRIGGERS MONOCYTE ARREST
- MOLECULE L-SELECTIN