L-selectin: Adhesion, signalling and its importance in pathologic posttraumatic endotoxemia and non-septic inflammation

T Barkhausen*, C Krettek, M van Griensven

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

18 Citations (Web of Science)

Abstract

The leucocyte expressed surface-bound L-selectin belongs to the selectin family of adhesion molecules. It exhibits adhesive as well as signalling functions. Mainly, it is of importance in lymphocyte homing and in the extravasation of leucocytes into the surrounding tissue during inflammation. Acting in the initial step of the cell adhesion cascade, L-selectin is responsible for the rolling of leucocytes on endothelial layers. Therefore, L-selectin is thought to be an adequate target for pharmacological interventions. Beneath the discussion of the molecules' general features like molecule structure and its regulation, the review focuses firstly on L-selectin in the context of posttraumatic inflammatory disorders, and secondly on the importance of L-selectin specific signalling events.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalExperimental and Toxicologic Pathology
Volume57
Issue number1
DOIs
Publication statusPublished - Aug 2005
Externally publishedYes

Keywords

  • L-selectin
  • adhesion
  • signal transduction
  • trauma
  • sepsis
  • SOLUBLE L-SELECTIN
  • TUMOR-NECROSIS-FACTOR
  • NODE HOMING RECEPTOR
  • LEUKOCYTE L-SELECTIN
  • SIALYL-LEWIS-X
  • ATTENUATES NEUTROPHIL ACCUMULATION
  • MYOCARDIAL REPERFUSION INJURY
  • MEMBRANE-PROXIMAL CLEAVAGE
  • TRIGGERS MONOCYTE ARREST
  • MOLECULE L-SELECTIN

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