Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Senta Jorinde Raasveld; Carolien Volleman; Alain Combes; Lars Mikael Broman; Fabio Silvio Taccone; Elma Peters; Sanne Ten Berg; Charissa E van den Brom; Holger Thiele; Roberto Lorusso; José P S Henriques; Alexander P J Vlaar

doi:10.1186/s40635-022-00478-z

Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Senta Jorinde Raasveld, Carolien Volleman, Alain Combes, Lars Mikael Broman, Fabio Silvio Taccone, Elma Peters, Sanne Ten Berg, Charissa E van den Brom, Holger Thiele, Roberto Lorusso, José P S Henriques, Alexander P J Vlaar^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

PURPOSE: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

METHODS: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.

RESULTS: After an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.

CONCLUSIONS: This scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population. Take-home message This scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.

Original language	English
Article number	50
Number of pages	17
Journal	Intensive Care Medicine Experimental
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40635-022-00478-z
Publication status	Published - 25 Nov 2022

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10.1186/s40635-022-00478-zLicence: CC BY

Cite this

Raasveld, S. J., Volleman, C., Combes, A., Broman, L. M., Taccone, F. S., Peters, E., Ten Berg, S., van den Brom, C. E., Thiele, H., Lorusso, R., Henriques, J. P. S., & Vlaar, A. P. J. (2022). Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review. Intensive Care Medicine Experimental, 10(1), Article 50. https://doi.org/10.1186/s40635-022-00478-z

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title = "Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review",

abstract = "PURPOSE: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).METHODS: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.RESULTS: After an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.CONCLUSIONS: This scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population. Take-home message This scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.",

author = "Raasveld, {Senta Jorinde} and Carolien Volleman and Alain Combes and Broman, {Lars Mikael} and Taccone, {Fabio Silvio} and Elma Peters and {Ten Berg}, Sanne and {van den Brom}, {Charissa E} and Holger Thiele and Roberto Lorusso and Henriques, {Jos{\'e} P S} and Vlaar, {Alexander P J}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = nov,

day = "25",

doi = "10.1186/s40635-022-00478-z",

language = "English",

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Raasveld, SJ, Volleman, C, Combes, A, Broman, LM, Taccone, FS, Peters, E, Ten Berg, S, van den Brom, CE, Thiele, H, Lorusso, R, Henriques, JPS & Vlaar, APJ 2022, 'Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review', Intensive Care Medicine Experimental, vol. 10, no. 1, 50. https://doi.org/10.1186/s40635-022-00478-z

TY - JOUR

T1 - Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation

T2 - a scoping review

AU - Raasveld, Senta Jorinde

AU - Volleman, Carolien

AU - Combes, Alain

AU - Broman, Lars Mikael

AU - Taccone, Fabio Silvio

AU - Peters, Elma

AU - Ten Berg, Sanne

AU - van den Brom, Charissa E

AU - Thiele, Holger

AU - Lorusso, Roberto

AU - Henriques, José P S

AU - Vlaar, Alexander P J

PY - 2022/11/25

Y1 - 2022/11/25

N2 - PURPOSE: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).METHODS: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.RESULTS: After an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.CONCLUSIONS: This scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population. Take-home message This scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.

AB - PURPOSE: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).METHODS: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.RESULTS: After an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.CONCLUSIONS: This scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population. Take-home message This scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.

U2 - 10.1186/s40635-022-00478-z

DO - 10.1186/s40635-022-00478-z

M3 - (Systematic) Review article

C2 - 36424482

SN - 2197-425X

VL - 10

JO - Intensive Care Medicine Experimental

JF - Intensive Care Medicine Experimental

IS - 1

M1 - 50

ER -