Irritable Bowel Syndrome: from diagnostic criteria to targeted treatment

Research output: ThesisDoctoral ThesisInternal

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Abstract

Transient receptor potential channels are promising targets for treatment of Irritable Bowel Syndrome (IBS). The TRPM8 channel can be stimulated by low temperatures and by menthol. We showed that intestinal TRPM8 expression is significantly higher in patients with IBS than healthy controls. The TRPM8 channel is colocalized with immune cells close to sensory nerve endings and its stimulation led to a reduction in pro-inflammatory cytokines. These findings suggest a role for TRPM8 in neuro-immune disease mechanisms in IBS. Menthol, which can stimulate the TRPM8 channel in the intestine, is the main constituent of peppermint oil. This research showed in a double-blind, randomized clinical trial of 189 IBS patients that small-intestinal release peppermint oil is a moderately effective treatment for irritable bowel syndrome with positive effects on IBS symptom severity, abdominal pain and abdominal discomfort. A trial-based cost-effectiveness analysis showed that peppermint oil appears to be cost-effective. Its use, which is low-cost, can therefore be justified by the effect on abdominal pain and the modest increase in quality of life in patients with IBS.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Masclee, Ad, Supervisor
  • Jonkers, Daisy, Supervisor
  • Keszthelyi, Daniel, Co-Supervisor
Award date15 Oct 2021
Place of PublicationMaastricht
Publisher
Print ISBNs9789464234213
DOIs
Publication statusPublished - 2021

Keywords

  • Irritable Bowel Syndrome
  • peppermint oil
  • transient receptor potential channels
  • cost-effectiveness

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