TY - JOUR
T1 - In Vivo Validation of Electrocardiographic Imaging
AU - Cluitmans, Matthijs J.M.
AU - Bonizzi, Pietro
AU - Karel, Joël M.H.
AU - Das, Marco
AU - Kietselaer, Bas L.J.H.
AU - Jong, Monique M.J. de
AU - Prinzen, Frits W.
AU - Peeters, Ralf L.M.
AU - Westra, Ronald L.
AU - Volders, Paul G.A.
PY - 2017
Y1 - 2017
N2 - The purpose of this study was to evaluate the accuracy of noninvasive reconstructions of epicardial potentials, electrograms, activation and recovery isochrones, and beat origins by simultaneously performing electrocardiographic imaging (ECGI) and invasive epicardial electrography in intact animals.Noninvasive imaging of electrical potentials at the epicardium, known as ECGI, is increasingly applied in patients to assess normal and abnormal cardiac electrical activity.Body-surface potentials and epicardial potentials were recorded in normal anesthetized dogs. Computed tomography scanning provided a torso-heart geometry that was used to reconstruct epicardial potentials from body-surface potentials.Electrogram reconstructions attained a moderate accuracy compared with epicardial recordings (median correlation coefficient: 0.71), but with considerable variation (interquartile range: 0.36 to 0.86). This variation could be explained by a spatial mismatch (overall resolution was
AB - The purpose of this study was to evaluate the accuracy of noninvasive reconstructions of epicardial potentials, electrograms, activation and recovery isochrones, and beat origins by simultaneously performing electrocardiographic imaging (ECGI) and invasive epicardial electrography in intact animals.Noninvasive imaging of electrical potentials at the epicardium, known as ECGI, is increasingly applied in patients to assess normal and abnormal cardiac electrical activity.Body-surface potentials and epicardial potentials were recorded in normal anesthetized dogs. Computed tomography scanning provided a torso-heart geometry that was used to reconstruct epicardial potentials from body-surface potentials.Electrogram reconstructions attained a moderate accuracy compared with epicardial recordings (median correlation coefficient: 0.71), but with considerable variation (interquartile range: 0.36 to 0.86). This variation could be explained by a spatial mismatch (overall resolution was
KW - cardiac electrophysiology
KW - electrocardiography
KW - inverse problem of electrocardiography
KW - noninvasive electrocardiographic imaging
U2 - 10.1016/j.jacep.2016.11.012
DO - 10.1016/j.jacep.2016.11.012
M3 - Article
C2 - 29759517
SN - 2405-500X
VL - 3
SP - 232
EP - 242
JO - JACC: Clinical Electrophysiology
JF - JACC: Clinical Electrophysiology
IS - 3
ER -