In Vivo Validation of Electrocardiographic Imaging

Matthijs J.M. Cluitmans, Pietro Bonizzi, Joël M.H. Karel, Marco Das, Bas L.J.H. Kietselaer, Monique M.J. de Jong, Frits W. Prinzen, Ralf L.M. Peeters, Ronald L. Westra, Paul G.A. Volders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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The purpose of this study was to evaluate the accuracy of noninvasive reconstructions of epicardial potentials, electrograms, activation and recovery isochrones, and beat origins by simultaneously performing electrocardiographic imaging (ECGI) and invasive epicardial electrography in intact animals.Noninvasive imaging of electrical potentials at the epicardium, known as ECGI, is increasingly applied in patients to assess normal and abnormal cardiac electrical activity.Body-surface potentials and epicardial potentials were recorded in normal anesthetized dogs. Computed tomography scanning provided a torso-heart geometry that was used to reconstruct epicardial potentials from body-surface potentials.Electrogram reconstructions attained a moderate accuracy compared with epicardial recordings (median correlation coefficient: 0.71), but with considerable variation (interquartile range: 0.36 to 0.86). This variation could be explained by a spatial mismatch (overall resolution was
Original languageEnglish
Pages (from-to)232 - 242
JournalJACC: Clinical Electrophysiology
Issue number3
Publication statusPublished - 2017


  • cardiac electrophysiology
  • electrocardiography
  • inverse problem of electrocardiography
  • noninvasive electrocardiographic imaging

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