TY - JOUR
T1 - Intrahepatic lipid content is independently associated with soluble E-selectin levels
T2 - The Maastricht study
AU - Brouwers, Martijn C G J
AU - Simons, Nynke
AU - Kooi, Marianne Eline
AU - de Ritter, Rianneke
AU - van Dongen, Martien C J M
AU - Eussen, Simone J P M
AU - Bekers, Otto
AU - Kooman, Jeroen
AU - van Greevenbroek, Marleen M J
AU - van der Kallen, Carla J H
AU - Schram, Miranda T
AU - Schaper, Nicolaas C
AU - Schalkwijk, Casper G
AU - Stehouwer, Coen D A
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022/8
Y1 - 2022/8
N2 - BACKGROUND: Evidence is accumulating that liver sinusoidal endothelial cells are involved in the pathogenesis of non-alcoholic fatty liver disease. Previous studies have suggested that the endothelial biomarker soluble E-selectin (sE-selectin) is to an important extent liver-derived.AIMS: To study the relationship of intrahepatic lipid (IHL) content with sE-selectin at the population level.METHODS: This study was conducted in participants of The Maastricht Study (n = 1,634), a population-based cohort study enriched with patients with type 2 diabetes. We assessed the cross-sectional association between IHL content, quantified by MRI, and sE-selectin via multivariable regression with adjustment for age, sex, type 2 diabetes, educational level, BMI, Dutch Healthy Diet index, physical activity, and the Matsuda index.RESULTS: Standardized IHL content was associated with (log) sE-selectin (age-, sex- and type 2 diabetes-adjusted regression coefficient [B]: 0.048 [95%CI:0.038;0.058], p<0.001), even after full adjustment (B: 0.030 [0.019;0.042], p<0.001). Such an association was not observed for soluble vascular cell adhesion molecule 1 (sVCAM-1) levels.CONCLUSION: IHL content is an independent determinant of sE-selectin at the population level. These findings support further studies to unravel the involvement of liver sinusoidal endothelial cells in the different stages of non-alcoholic fatty liver disease and the specific role of E-selectin herein.
AB - BACKGROUND: Evidence is accumulating that liver sinusoidal endothelial cells are involved in the pathogenesis of non-alcoholic fatty liver disease. Previous studies have suggested that the endothelial biomarker soluble E-selectin (sE-selectin) is to an important extent liver-derived.AIMS: To study the relationship of intrahepatic lipid (IHL) content with sE-selectin at the population level.METHODS: This study was conducted in participants of The Maastricht Study (n = 1,634), a population-based cohort study enriched with patients with type 2 diabetes. We assessed the cross-sectional association between IHL content, quantified by MRI, and sE-selectin via multivariable regression with adjustment for age, sex, type 2 diabetes, educational level, BMI, Dutch Healthy Diet index, physical activity, and the Matsuda index.RESULTS: Standardized IHL content was associated with (log) sE-selectin (age-, sex- and type 2 diabetes-adjusted regression coefficient [B]: 0.048 [95%CI:0.038;0.058], p<0.001), even after full adjustment (B: 0.030 [0.019;0.042], p<0.001). Such an association was not observed for soluble vascular cell adhesion molecule 1 (sVCAM-1) levels.CONCLUSION: IHL content is an independent determinant of sE-selectin at the population level. These findings support further studies to unravel the involvement of liver sinusoidal endothelial cells in the different stages of non-alcoholic fatty liver disease and the specific role of E-selectin herein.
KW - ENDOTHELIAL DYSFUNCTION
KW - FATTY LIVER
KW - NASH
KW - Non-alcoholic fatty liver disease
KW - RISK
KW - Sinusoidal endothelial cell
U2 - 10.1016/j.dld.2022.01.130
DO - 10.1016/j.dld.2022.01.130
M3 - Article
C2 - 35135742
SN - 1590-8658
VL - 54
SP - 1038
EP - 1043
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 8
ER -