Interplay between platelets and coagulation

Yaqiu Sang, Mark Roest, Bas de Laat, Philip G. de Groot, Dana Huskens*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Citations (Web of Science)

Abstract

Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood vessels through clot formation. This regulated physiological process consists of complex interactions between endothelial cells, platelets, von Willebrand factor and coagulation factors. Haemostasis is initiated by a damaged vessel wall, followed with a rapid adhesion, activation and aggregation of platelets to the exposed subendothelial extra cellular matrix. At the same time, coagulation factors aggregate on the procoagulant surface of activated platelets to consolidate the platelet plug by forming a mesh of cross-linked fibrin. Platelets and coagulation mutually influence each other and there are strong indications that, thanks to the interplay between platelets and coagulation, haemostasis is far more effective than the two processes separately. Clinically this is relevant because impaired interaction between platelets and coagulation may result in bleeding complications, while excessive platelet-coagulation interaction induces a high thrombotic risk. In this review, platelets, coagulation factors and the complex interaction between them will be discussed in detail.

Original languageEnglish
Article number100733
Number of pages11
JournalBlood Reviews
Volume46
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Platelet
  • Coagulation
  • Haemostasis
  • Platelet-based coagulation
  • Clinical disorders
  • GLYCOPROTEIN IB-IX
  • TISSUE FACTOR PATHWAY
  • MOLECULAR-WEIGHT KININOGEN
  • VON-WILLEBRAND-FACTOR
  • DEEP-VEIN THROMBOSIS
  • PROTEASE-ACTIVATED RECEPTORS
  • RECOMBINANT FACTOR VIIA
  • FACTOR-V DEFICIENCY
  • XI MESSENGER-RNA
  • BINDING-SITE

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