TY - JOUR
T1 - International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results
AU - Damoiseaux, Jan
AU - von Muhlen, Carlos A.
AU - Garcia-De La Torre, Ignacio
AU - Gabriel Carballo, Orlando
AU - Cruvinel, Wilson de Melo
AU - Carvalho Francescantonio, Paulo Luiz
AU - Fritzler, Marvin J.
AU - Herold, Manfred
AU - Mimori, Tsuneyo
AU - Satoh, Minoru
AU - Andrade, Luis E. C.
AU - Chan, Edward K. L.
AU - Conrad, Karsten
PY - 2016
Y1 - 2016
N2 - The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. This report outlines the issues that impact on two major different reporting methods. Although it was appreciated by all participants that cytoplasmic and mitotic patterns are clinically relevant, implications for existing diagnostic/classification criteria for ANA-associated diseases in particular hampered a final consensus on this topic. Evidently, a more concerted action of all relevant stake-holders is required. Future ICAP workshops may help to facilitate this action.
AB - The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. This report outlines the issues that impact on two major different reporting methods. Although it was appreciated by all participants that cytoplasmic and mitotic patterns are clinically relevant, implications for existing diagnostic/classification criteria for ANA-associated diseases in particular hampered a final consensus on this topic. Evidently, a more concerted action of all relevant stake-holders is required. Future ICAP workshops may help to facilitate this action.
KW - Anti-nuclear antibodies
KW - Indirect immunofluorescence
KW - Nuclear patterns
KW - Cytoplasmic patterns
KW - Mitotic patterns
KW - Harmonization
U2 - 10.1007/s13317-016-0075-0
DO - 10.1007/s13317-016-0075-0
M3 - Article
VL - 7
JO - Autoimmunity Highlights
JF - Autoimmunity Highlights
SN - 2038-0305
IS - 1
M1 - 1
ER -