In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 1 Jan 2009|
Geraets, L., Haegens, A., Brauers, K., Haydock, J. A., Vernooy, J. H., Wouters, E. F., Bast, A., & Hageman, G. J. (2009). Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochemical and Biophysical Research Communications, 382(3), 598-603. https://doi.org/10.1016/j.bbrc.2009.03.071