Inhibition of LPS-induced pulmonary inflammation by specific flavonoids

L. Geraets; A. Haegens; K. Brauers; J.A. Haydock; J.H. Vernooy; E.F. Wouters; A. Bast; G.J. Hageman

doi:10.1016/j.bbrc.2009.03.071

Inhibition of LPS-induced pulmonary inflammation by specific flavonoids

L. Geraets^*, A. Haegens, K. Brauers, J.A. Haydock, J.H. Vernooy, E.F. Wouters, A. Bast, G.J. Hageman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.

Original language	English
Pages (from-to)	598-603
Journal	Biochemical and Biophysical Research Communications
Volume	382
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2009.03.071
Publication status	Published - 1 Jan 2009

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title = "Inhibition of LPS-induced pulmonary inflammation by specific flavonoids",

abstract = "In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.",

author = "L. Geraets and A. Haegens and K. Brauers and J.A. Haydock and J.H. Vernooy and E.F. Wouters and A. Bast and G.J. Hageman",

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T1 - Inhibition of LPS-induced pulmonary inflammation by specific flavonoids

AU - Geraets, L.

AU - Haegens, A.

AU - Brauers, K.

AU - Haydock, J.A.

AU - Vernooy, J.H.

AU - Wouters, E.F.

AU - Bast, A.

AU - Hageman, G.J.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.

AB - In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.

U2 - 10.1016/j.bbrc.2009.03.071

DO - 10.1016/j.bbrc.2009.03.071

M3 - Article

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Inhibition of LPS-induced pulmonary inflammation by specific flavonoids

Abstract

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