Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population

S Bonneux, E Fransen, E Van Eyken, L Van Laer, J Huyghe, P Van de Heyning, A Voets, M Gerards, A P M Stassen, A T M Hendrickx, H J M Smeets, G Van Camp

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8 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.

Original languageEnglish
Pages (from-to)729-734
Number of pages6
JournalMitochondrion
Volume11
Issue number5
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Aged
  • Belgium
  • Genes, Mitochondrial
  • Genetic Association Studies
  • Haplotypes
  • Heredity
  • Humans
  • Middle Aged
  • Mitochondria
  • Mutation
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Presbycusis
  • Risk Factors
  • Sequence Analysis, DNA
  • Statistics, Nonparametric

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