Inflammatory signaling in skeletal muscle insulin resistance: green signal for nutritional intervention?

P.P. Hommelberg, R.C.J. Langen, A.M.W.J. Schols, R.P. Mensink*, J. Plat

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


PURPOSE OF REVIEW: To review the evidence implying a role of inflammatory signaling pathways, specifically nuclear factor-kappaB and c-Jun NH2-terminal kinase, in fatty acid-induced skeletal muscle insulin resistance and to discuss the potential of dietary interventions to interfere with these processes. RECENT FINDINGS: Fatty acids can induce skeletal muscle insulin resistance via inflammatory signaling after binding Toll-like receptors at the cell membrane of muscle cells or after accumulating as intramyocellular lipid metabolites. In both processes, activation of intracellular inflammatory signaling is involved. The majority of literature addressing the causality of muscle nuclear factor-kappaB activation in skeletal muscle insulin resistance suggests that insulin resistance does not require muscle nuclear factor-kappaB activation. Recently, strong evidence was given that c-Jun NH2-terminal kinase signaling is an important inflammatory pathway involved in skeletal muscle insulin resistance. Furthermore, it is well established that proinflammatory cytokines originating from the enlarged adipose tissue or from activated adipose tissue macrophages can cause muscle insulin resistance. Recently, also macrophages resided in the muscle have been proposed to play an important role in muscle insulin resistance. Because of their anti-inflammatory characteristics, several dietary components like polyphenols may be interesting candidates for manipulating skeletal muscle insulin resistance. SUMMARY: Several dietary components, like polyphenols, have been reported to interfere with inflammatory signaling. To test whether these compounds can be used to prevent or reverse insulin resistance, well controlled human intervention studies have to be designed.
Original languageEnglish
Pages (from-to)647-655
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number6
Publication statusPublished - 1 Jan 2010

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