Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Tim G. A. M. Wolfs, Reint K. Jellema, Giovanni Turrisi, Elisa Becucci, Giuseppe Buonocore, Boris W. Kramer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Chorioamnionitis which results from microbial invasion of the amniotic cavity is the most frequent cause of preterm birth. Chorioamnionitis is associated with an increased risk of early-onset sepsis but the mechanisms underlying this association remain largely unknown. We hypothesize that developmental alterations of fetal organs and the immune system in the course of chorioamnionitis determine the risk of development of early onset sepsis. The purpose of this review is therefore to summarize the consequences of chorioamnionitis on fetal development and speculate how those antenatal changes might predispose to early onset sepsis.
Original languageEnglish
Pages (from-to)8-11
JournalJournal of Maternal-Fetal & Neonatal Medicine
Publication statusPublished - Apr 2012


  • developmental origin of Health and disease
  • gut and lung development
  • immune competence
  • chorioamnionitis

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