Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This is Not Due to Diabetes: A Population-Based Cohort Study

J.M.A. Wijnands, C.M.P.G. van Durme, J.H.M. Driessen, A. Boonen, C. Klop, B. Leufkens, C. Cooper, C.D.A. Stehouwer, F. de Vries

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Abstract

The relationship between type 2 diabetes and gout is complex. The objective of this study was to understand the role of diabetes itself and its comorbidities within the association between type 2 diabetes and gout.We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (CPRD) GOLD. Persons with type 2 diabetes were identified as persons on a noninsulin antidiabetic drug (NIAD) between 2004 and 2012, and were matched to 1 control based on age, sex, and general practice. We estimated gout risk in NIAD users using Cox regression analysis. All analyses were stratified for sex.In total, 221,117 NIAD users were identified. NIAD users had an increased risk of gout (hazard ratio (HR) 1.48; 95% CI 1.41-1.54). This association was stronger in women (HR 2.23; 95% CI 2.07-2.41) compared with men (HR 1.19; 95% CI 1.13-1.26). After adjustments for BMI, eGFR, hypertension, renal transplantation, diuretics, statins, low-dose aspirin, ciclosporin, and tacrolimus, the risk disappeared in women (HR 1.01; 95% CI 0.92-1.11) and reversed in men (HR 0.61; 95% CI 0.58-0.66) (P for interaction
Original languageEnglish
Article numbere1358
JournalMedicine
Volume94
Issue number32
DOIs
Publication statusPublished - 1 Jan 2015

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