Abstract
Advanced glycation end-products (AGEs) are implicated in the pathogenesis of vascular disease. In previous studies we have found increased deposition of N(e)-(carboxymethyl)lysine (CML) in intramyocardial vasculature in the heart in acute myocardial infarction and myocarditis. It is known that the process of inflammation plays a role in the formation of AGEs. In this study we have explored the presence of CML (a major AGE) in the heart of patients with epicarditis using a monoclonal anti-CML antibody. Nine patients with epicarditis (n?=?9) died and their hearts were used for this study, control were hearts from patients who died from conditions unrelated to heart disease and without signs of myocarditis or epicarditis CML deposition and complement were significantly increased in patients with epicarditis compared to control hearts. Thus epicarditis increases CML depositions in the intramyocardial vasculature.
Original language | English |
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Pages (from-to) | 48-51 |
Number of pages | 4 |
Journal | International Journal of Experimental Pathology |
Volume | 105 |
Issue number | 2 |
Early online date | 8 Dec 2023 |
DOIs | |
Publication status | Published - Apr 2024 |
Keywords
- AGE's
- epicarditis
- intramyocardial vasculature