Inconsistency in large pharmacogenomic studies

Benjamin Haibe-Kains*, Nehme El-Hachem, Nicolai Juul Birkbak, Andrew C. Jin, Andrew H. Beck, Hugo J. W. L. Aerts, John Quackenbush

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

312 Citations (Web of Science)

Abstract

Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.
Original languageEnglish
Pages (from-to)389-+
JournalNature
Volume504
Issue number7480
DOIs
Publication statusPublished - 19 Dec 2013

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