Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

Nienke M. van Loon; Roelof Ottenhoff; Sander Kooijman; Martina Moeton; Saskia Scheij; Reinout L. P. Roscam Abbing; Marion J. J. Gijbels; Johannes H. M. Levels; Vincenzo Sorrentino; Jimmy F. P. Berbee; Patrick C. N. Rensen; Noam Zelcer

doi:10.1161/ATVBAHA.118.311168

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

Nienke M. van Loon, Roelof Ottenhoff, Sander Kooijman, Martina Moeton, Saskia Scheij, Reinout L. P. Roscam Abbing, Marion J. J. Gijbels, Johannes H. M. Levels, Vincenzo Sorrentino, Jimmy F. P. Berbee, Patrick C. N. Rensen, Noam Zelcer

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1785-1795
Number of pages	11
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	38
Issue number	8
DOIs	https://doi.org/10.1161/ATVBAHA.118.311168
Publication status	Published - 1 Aug 2018

Keywords

adipose tissue
brown
cholesterol
lipid metabolism
metabolic syndrome
obesity
ubiquitin-protein ligases
LOW-DENSITY-LIPOPROTEIN
FAMILY-MEMBERS VLDLR
ADIPOSE-TISSUE
INDUCIBLE DEGRADER
LDL RECEPTORS
CHOLESTEROL
PCSK9
DEGRADATION
PLASMA
GLUCOSE

Access to Document

10.1161/ATVBAHA.118.311168

Cite this

van Loon, N. M., Ottenhoff, R., Kooijman, S., Moeton, M., Scheij, S., Abbing, R. L. P. R., Gijbels, M. J. J., Levels, J. H. M., Sorrentino, V., Berbee, J. F. P., Rensen, P. C. N., & Zelcer, N. (2018). Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 38(8), 1785-1795. https://doi.org/10.1161/ATVBAHA.118.311168

van Loon, Nienke M. ; Ottenhoff, Roelof ; Kooijman, Sander ; Moeton, Martina ; Scheij, Saskia ; Abbing, Reinout L. P. Roscam ; Gijbels, Marion J. J. ; Levels, Johannes H. M. ; Sorrentino, Vincenzo ; Berbee, Jimmy F. P. ; Rensen, Patrick C. N. ; Zelcer, Noam. / Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. In: Arteriosclerosis Thrombosis and Vascular Biology. 2018 ; Vol. 38, No. 8. pp. 1785-1795.

@article{dc91a0ec391043feb35e2a8e69dd61dd,

title = "Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice",

keywords = "adipose tissue, brown, cholesterol, lipid metabolism, metabolic syndrome, obesity, ubiquitin-protein ligases, LOW-DENSITY-LIPOPROTEIN, FAMILY-MEMBERS VLDLR, ADIPOSE-TISSUE, INDUCIBLE DEGRADER, LDL RECEPTORS, CHOLESTEROL, PCSK9, DEGRADATION, PLASMA, GLUCOSE",

author = "{van Loon}, {Nienke M.} and Roelof Ottenhoff and Sander Kooijman and Martina Moeton and Saskia Scheij and Abbing, {Reinout L. P. Roscam} and Gijbels, {Marion J. J.} and Levels, {Johannes H. M.} and Vincenzo Sorrentino and Berbee, {Jimmy F. P.} and Rensen, {Patrick C. N.} and Noam Zelcer",

year = "2018",

month = aug,

day = "1",

doi = "10.1161/ATVBAHA.118.311168",

language = "English",

volume = "38",

pages = "1785--1795",

journal = "Arteriosclerosis Thrombosis and Vascular Biology",

issn = "1079-5642",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

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van Loon, NM, Ottenhoff, R, Kooijman, S, Moeton, M, Scheij, S, Abbing, RLPR, Gijbels, MJJ, Levels, JHM, Sorrentino, V, Berbee, JFP, Rensen, PCN & Zelcer, N 2018, 'Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice', Arteriosclerosis Thrombosis and Vascular Biology, vol. 38, no. 8, pp. 1785-1795. https://doi.org/10.1161/ATVBAHA.118.311168

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. / van Loon, Nienke M.; Ottenhoff, Roelof; Kooijman, Sander; Moeton, Martina; Scheij, Saskia; Abbing, Reinout L. P. Roscam; Gijbels, Marion J. J.; Levels, Johannes H. M.; Sorrentino, Vincenzo; Berbee, Jimmy F. P.; Rensen, Patrick C. N.; Zelcer, Noam.

In: Arteriosclerosis Thrombosis and Vascular Biology, Vol. 38, No. 8, 01.08.2018, p. 1785-1795.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

AU - van Loon, Nienke M.

AU - Ottenhoff, Roelof

AU - Kooijman, Sander

AU - Moeton, Martina

AU - Scheij, Saskia

AU - Abbing, Reinout L. P. Roscam

AU - Gijbels, Marion J. J.

AU - Levels, Johannes H. M.

AU - Sorrentino, Vincenzo

AU - Berbee, Jimmy F. P.

AU - Rensen, Patrick C. N.

AU - Zelcer, Noam

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KW - adipose tissue

KW - brown

KW - cholesterol

KW - lipid metabolism

KW - metabolic syndrome

KW - obesity

KW - ubiquitin-protein ligases

KW - LOW-DENSITY-LIPOPROTEIN

KW - FAMILY-MEMBERS VLDLR

KW - ADIPOSE-TISSUE

KW - INDUCIBLE DEGRADER

KW - LDL RECEPTORS

KW - CHOLESTEROL

KW - PCSK9

KW - DEGRADATION

KW - PLASMA

KW - GLUCOSE

U2 - 10.1161/ATVBAHA.118.311168

DO - 10.1161/ATVBAHA.118.311168

M3 - Article

VL - 38

SP - 1785

EP - 1795

JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

SN - 1079-5642

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ER -