Implementation of a rapid learning platform: Predicting 2-year survival in laryngeal carcinoma patients in a clinical setting.

Tim Lustberg, Michael Bailey, David I Thwaites, Alexis Miller, Martin Carolan, Lois Holloway, Emmanuel Rios Velazquez, Frank Hoebers, Andre Dekker

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background and PurposeTo improve quality and personalization of oncology health care, decision aid tools are needed to advise physicians and patients. The aim of this work is to demonstrate the clinical relevance of a survival prediction model as a first step to multi institutional rapid learning and compare this to a clinical trial dataset.Material and MethodsData extraction and mining tools were used to collect uncurated input parameters from Illawarra Cancer Care Centre's (clinical cohort) oncology information system. Prognosis categories previously established from the Maastricht Radiation Oncology (training cohort) dataset, were applied to the clinical cohort and the radiotherapy only arm of the RTOG-9111 (trial cohort).ResultsData mining identified 125 laryngeal carcinoma patients, ending up with 52 patients in the clinical cohort who were eligible to be evaluated by the model to predict 2-year survival and 177 for the trial cohort. The model was able to classify patients and predict survival in the clinical cohort, but for the trial cohort it failed to do so.ConclusionsThe technical infrastructure and model is able to support the prognosis prediction of laryngeal carcinoma patients in a clinical cohort. The model does not perform well for the highly selective patient population in the trial cohort.
Original languageEnglish
Pages (from-to)37288-37296
JournalOncoTarget
Volume7
Issue number24
DOIs
Publication statusPublished - 15 Apr 2016

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