E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

Alexandra Marie Mowday, Janine Naomi Copp, Sophie Philippa Syddall, Ludwig Jerome Dubois, Jingli Wang, Natasja Gabi Lieuwes, Rianne Biemans, Amir Ashoorzadeh, Maria Rosaria Abbattista, Elsie May Williams, Christopher Paul Guise, Philippe Lambin, David Francis Ackerley, Jeff Bruce Smaill, Jan Theys, Adam Vorn Patterson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)
Original languageEnglish
Pages (from-to)10548-10562
Number of pages15
JournalTheranostics
Volume10
Issue number23
DOIs
Publication statusPublished - 2020

Keywords

  • reporter gene imaging
  • PET imaging
  • nitroreductase
  • gene therapy
  • drug repurposing
  • POSITRON-EMISSION-TOMOGRAPHY
  • BIOREDUCTIVE PRODRUG PR-104A
  • PHASE-I
  • ANTITUMOR-ACTIVITY
  • TUMOR HYPOXIA
  • EXPRESSION
  • ACTIVATE
  • OXIDOREDUCTASE
  • BIOMARKER
  • ABLATION

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