TY - JOUR
T1 - Identification of Metabolic Factors and Inflammatory Markers Predictive of Outcome after Total Knee Arthroplasty in Patients with Knee Osteoarthritis
T2 - A Systematic Review
AU - Meert, Lotte
AU - Mertens, Michel G.C.A.M.
AU - Meeus, Mira
AU - Vervullens, Sophie
AU - Baert, Isabel
AU - Beckwée, David
AU - Verdonk, Peter
AU - Smeets, Rob J.E.M.
N1 - Funding Information:
Lotte Meert is a PhD research fellow funded by the Research Foundation Flanders (FWO) [11E5720N].
Publisher Copyright:
© 2023 by the authors.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Objective: To identify metabolic factors and inflammatory markers that are predictive of postoperative total knee arthroplasty (TKA) outcome. Method: A systematic search of the existing literature was performed using the electronic databases PubMed, Web of Science and Embase until the 1st of August 2022. Studies that evaluated the influence of metabolic or inflammatory markers (I) on postsurgical outcome (O) in end-stage knee osteoarthritis patients awaiting primary TKA (P) were included in this review. Results: In total, 49 studies were included. Risk of bias of the included studies was low for one study, moderate for 10 studies and high for the remaining 38 studies. Conflicting evidence was found for the influence of body mass index, diabetes, cytokine levels and dyslipidaemia on pain, function, satisfaction and quality of life at more than six months after TKA. Conclusions: Several limitations such as not taking into account known confounding factors, the use of many different outcome measures and a widely varying follow-up period made it challenging to draw firm conclusions and clinical implications. Therefore large-scaled longitudinal studies assessing the predictive value of metabolic and inflammatory factors pre-surgery in addition to the already evidenced risk factors with follow-up of one year after TKA are warranted.
AB - Objective: To identify metabolic factors and inflammatory markers that are predictive of postoperative total knee arthroplasty (TKA) outcome. Method: A systematic search of the existing literature was performed using the electronic databases PubMed, Web of Science and Embase until the 1st of August 2022. Studies that evaluated the influence of metabolic or inflammatory markers (I) on postsurgical outcome (O) in end-stage knee osteoarthritis patients awaiting primary TKA (P) were included in this review. Results: In total, 49 studies were included. Risk of bias of the included studies was low for one study, moderate for 10 studies and high for the remaining 38 studies. Conflicting evidence was found for the influence of body mass index, diabetes, cytokine levels and dyslipidaemia on pain, function, satisfaction and quality of life at more than six months after TKA. Conclusions: Several limitations such as not taking into account known confounding factors, the use of many different outcome measures and a widely varying follow-up period made it challenging to draw firm conclusions and clinical implications. Therefore large-scaled longitudinal studies assessing the predictive value of metabolic and inflammatory factors pre-surgery in addition to the already evidenced risk factors with follow-up of one year after TKA are warranted.
KW - chronic pain
KW - knee osteoarthritis
KW - low-grade inflammation
KW - metabolic factors
KW - postoperative outcome
KW - systematic review
KW - total knee arthroplasty
U2 - 10.3390/ijerph20105796
DO - 10.3390/ijerph20105796
M3 - (Systematic) Review article
C2 - 37239524
SN - 1660-4601
VL - 20
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 10
M1 - 5796
ER -