Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics

Evelyn Smit, Terezinha Souza, Danyel G. J. Jennen, Jos C. S. Kleinjans, Twan van den Beucken*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)74-82
Number of pages9
JournalToxicology
Volume390
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Gene expression
  • Aflatoxin B1
  • Benzo(a)pyrene
  • shRNA screen
  • Transcription factor
  • NUCLEOTIDE EXCISION-REPAIR
  • GENE-EXPRESSION PROFILE
  • HEPG2 CELLS
  • H2AX PHOSPHORYLATION
  • EPITHELIAL-CELLS
  • HISTONE H2AX
  • HUMAN LIVER
  • P53 FAMILY
  • IN-VIVO
  • GENOTOXICITY

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