How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1

Enrico Finazzi Agro; Eleonora Rosato; Adrian Wagg; Sanjay Sinha; Claudia Fede Spicchiale; Maurizio Serati; Vito Mancini; Mathijs de Rijk; Tufan Tarcan; Alan Wein; Paul Abrams; George Bou Kheir

doi:10.1002/nau.25377

How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1

Enrico Finazzi Agro^*, Eleonora Rosato, Adrian Wagg, Sanjay Sinha, Claudia Fede Spicchiale, Maurizio Serati, Vito Mancini, Mathijs de Rijk, Tufan Tarcan, Alan Wein, Paul Abrams, George Bou Kheir

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

IntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.

Original language	English
Number of pages	11
Journal	Neurourology and Urodynamics
DOIs	https://doi.org/10.1002/nau.25377
Publication status	E-pub ahead of print - 1 Jan 2024

Keywords

affective disorders
autonomic nervous system dysfunction
gastrointestinal disorders
metabolic syndrome
microbiome
overactive bladder
underactive bladder
OVERACTIVE BLADDER SYNDROME
IRRITABLE-BOWEL-SYNDROME
METABOLIC SYNDROME
TRACT SYMPTOMS
GLYCEMIC CONTROL
RISK-FACTORS
DIABETES-MELLITUS
INCONTINENCE
ASSOCIATION
WOMEN

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Agro, E. F., Rosato, E., Wagg, A., Sinha, S., Spicchiale, C. F., Serati, M., Mancini, V., de Rijk, M., Tarcan, T., Wein, A., Abrams, P., & Kheir, G. B. (2024). How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1. Neurourology and Urodynamics. Advance online publication. https://doi.org/10.1002/nau.25377

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title = "How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1",

abstract = "IntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.",

keywords = "affective disorders, autonomic nervous system dysfunction, gastrointestinal disorders, metabolic syndrome, microbiome, overactive bladder, underactive bladder, OVERACTIVE BLADDER SYNDROME, IRRITABLE-BOWEL-SYNDROME, METABOLIC SYNDROME, TRACT SYMPTOMS, GLYCEMIC CONTROL, RISK-FACTORS, DIABETES-MELLITUS, INCONTINENCE, ASSOCIATION, WOMEN",

author = "Agro, {Enrico Finazzi} and Eleonora Rosato and Adrian Wagg and Sanjay Sinha and Spicchiale, {Claudia Fede} and Maurizio Serati and Vito Mancini and {de Rijk}, Mathijs and Tufan Tarcan and Alan Wein and Paul Abrams and Kheir, {George Bou}",

year = "2024",

month = jan,

day = "1",

doi = "10.1002/nau.25377",

language = "English",

journal = "Neurourology and Urodynamics",

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Agro, EF, Rosato, E, Wagg, A, Sinha, S, Spicchiale, CF, Serati, M, Mancini, V, de Rijk, M, Tarcan, T, Wein, A, Abrams, P & Kheir, GB 2024, 'How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1', Neurourology and Urodynamics. https://doi.org/10.1002/nau.25377

How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1. / Agro, Enrico Finazzi; Rosato, Eleonora; Wagg, Adrian et al.
In: Neurourology and Urodynamics, 01.01.2024.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023

T2 - Part 1

AU - Agro, Enrico Finazzi

AU - Rosato, Eleonora

AU - Wagg, Adrian

AU - Sinha, Sanjay

AU - Spicchiale, Claudia Fede

AU - Serati, Maurizio

AU - Mancini, Vito

AU - de Rijk, Mathijs

AU - Tarcan, Tufan

AU - Wein, Alan

AU - Abrams, Paul

AU - Kheir, George Bou

PY - 2024/1/1

Y1 - 2024/1/1

N2 - IntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.

AB - IntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.

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KW - autonomic nervous system dysfunction

KW - gastrointestinal disorders

KW - metabolic syndrome

KW - microbiome

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KW - underactive bladder

KW - OVERACTIVE BLADDER SYNDROME

KW - IRRITABLE-BOWEL-SYNDROME

KW - METABOLIC SYNDROME

KW - TRACT SYMPTOMS

KW - GLYCEMIC CONTROL

KW - RISK-FACTORS

KW - DIABETES-MELLITUS

KW - INCONTINENCE

KW - ASSOCIATION

KW - WOMEN

U2 - 10.1002/nau.25377

DO - 10.1002/nau.25377

M3 - Article

SN - 0733-2467

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

ER -