@article{dc0da8a885ff4d0c940038287ddf6261,
title = "Host microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease",
abstract = "Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.",
keywords = "OBSTRUCTIVE PULMONARY-DISEASE, OUTER-MEMBRANE VESICLES, ALLERGIC AIRWAY DISEASE, INTESTINAL MICROBIOTA, GUT MICROBIOTA, IMMUNE-RESPONSES, HAEMOPHILUS-INFLUENZAE, RESPIRATORY MICROBIOTA, EPITHELIAL-CELLS, CYSTIC-FIBROSIS",
author = "Reinoud Gosens and Hiemstra, {Pieter S.} and Adcock, {Ian M.} and Bracke, {Ken R.} and Dickson, {Robert P.} and Hansbro, {Philip M.} and Susanne Krauss-Etschmann and Smits, {Hermelijn H.} and Stassen, {Frank R. M.} and Sabine Bartel",
note = "Funding Information: Support statement: P.M. Hansbro is funded by a Fellowship and grants from the National Health and Medical Research Council (#1079187, 1059238), the Rainbow Foundation and the University of Technology Sydney. S. Krauss-Etschmann is a member of the Leibniz Competition 2016 “The Lung Microbiota at the Interface between Airway Epithelium and Environment” and the Leibniz Science Campus “Evolung”. H.H. Smits is supported by a ZonMW-VIDI grant (91714352) from The Netherlands Organisation for Scientific Research, and both H.H. Smits and P.S. Hiemstra are supported by a consortium grant (#5115015) from the Netherlands Lung Foundation (NLF) and by a grant (#12017001) from the NLF Accelerate Programme. R. Gosens and P.S. Hiemstra are supported by a consortium grant (6114009) from the NLF. Funding information for this article has been deposited with the Crossref Funder Registry. Funding Information: Conflict of interest: R. Gosens reports grants from Novartis, Boehringer Ingelheim, Aquilo and Chiesi, outside the submitted work. P.S. Hiemstra reports grants from Boehringer Ingelheim and Galapagos N.V., outside the submitted work. I.M. Adcock reports personal fees for lectures from AstraZeneca and Sunovion, grants from Boehringer Ingelheim, outside the submitted work. K.R. Bracke has nothing to disclose. R.P. Dickson has nothing to disclose. P.M. Hansbro has nothing to disclose. S. Krauss-Etschmann has nothing to disclose. H.H. Smits has nothing to disclose. F.R.M. Stassen has nothing to disclose. S. Bartel reports grants and personal fees for advisory board work from Bencard Allergie GmbH, outside the submitted work. Publisher Copyright: Copyright {\textcopyright} ERS 2020. This version is distributed under the terms of the Creative Commons Attribution NonCommercial Licence 4.0.",
year = "2020",
month = aug,
day = "1",
doi = "10.1183/13993003.02320-2019",
language = "English",
volume = "56",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "2",
}