Histopathology of human small intestinal and colonic ischemia-reperfusion: Experiences from human IR-models

Claire A. J. Leenarts*, Joep Grootjans, Inca H. Hundscheid, Dirk H. S. M. Schellekens, Kaatje Lenaerts, Wim A. Buurman, Cornelis H. C. Dejong, Joep P. M. Derikx

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Web of Science)

Abstract

Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition.

Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Over the past decade, we have studied the pathophysiology of human small intestinal and colonic ischemia-reperfusion (IR) in newly developed human in vivo IR models. In this review, we give an overview of new insights on the sequelae of human intestinal IR, with particular attention for the differences in histopathology between small intestinal and colonic IR.

Original languageEnglish
Pages (from-to)711-722
Number of pages12
JournalHistology and Histopathology
Volume34
Issue number7
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Human
  • Intestine
  • Ischemia-reperfusion
  • Histology
  • ACUTE MESENTERIC ISCHEMIA
  • ACID-BINDING PROTEIN
  • SYSTEMIC INFLAMMATION
  • DIGESTIVE ENZYMES
  • MUCUS LAYERS
  • INJURY
  • BARRIER
  • DAMAGE
  • INHIBITION
  • PERMEABILITY

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