Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms

Helke A. Van Dessel; Jeanne A.M.C. Dirks; Inge H.M. Van Loo; Brian M.J.W. Van Der Veer; Christian J.P.A. Hoebe; Nicole H.T.M. Dukers-Muijrers; Paul H.M. Savelkoul; Petra Wolffs

doi:10.1136/sextrans-2023-055977

Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms

Helke A. Van Dessel, Jeanne A.M.C. Dirks^*, Inge H.M. Van Loo, Brian M.J.W. Van Der Veer, Christian J.P.A. Hoebe, Nicole H.T.M. Dukers-Muijrers, Paul H.M. Savelkoul, Petra Wolffs

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) coinfections are commonly reported; in high-risk groups up to 40% of those infected with NG are also infected with CT.1 While coinfections might happen accidentally, it has been mathematically proven that it occurs much more frequently than can be expected from random chance alone.2 However, little is known about the effect of coinfections on pathogenesis, bacterial load, transmission and disease severity. Prior studies in this field are scarce and with contradictory results.1 To address this knowledge gap we looked at the effect of NG/CT coinfections on the NG bacterial load, and how coinfections with CT influence symptom severity of NG infections.

Original language	English
Pages (from-to)	127-128
Number of pages	2
Journal	Sexually Transmitted Infections
Volume	100
Issue number	2
Early online date	1 Jan 2023
DOIs	https://doi.org/10.1136/sextrans-2023-055977
Publication status	Published - 29 Nov 2023

Keywords

Bacterial Infections
Chalmydia Trachomatis
NEISSERIA GONORRHOEAE

Access to Document

10.1136/sextrans-2023-055977

Cite this

Van Dessel, H. A., Dirks, J. A. M. C., Van Loo, I. H. M., Van Der Veer, B. M. J. W., Hoebe, C. J. P. A., Dukers-Muijrers, N. H. T. M., Savelkoul, P. H. M., & Wolffs, P. (2023). Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms. Sexually Transmitted Infections, 100(2), 127-128. https://doi.org/10.1136/sextrans-2023-055977

@article{238d6e32c26b404281ca938aa9389bae,

title = "Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms",

abstract = "Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) coinfections are commonly reported; in high-risk groups up to 40% of those infected with NG are also infected with CT.1 While coinfections might happen accidentally, it has been mathematically proven that it occurs much more frequently than can be expected from random chance alone.2 However, little is known about the effect of coinfections on pathogenesis, bacterial load, transmission and disease severity. Prior studies in this field are scarce and with contradictory results.1 To address this knowledge gap we looked at the effect of NG/CT coinfections on the NG bacterial load, and how coinfections with CT influence symptom severity of NG infections.",

keywords = "Bacterial Infections, Chalmydia Trachomatis, NEISSERIA GONORRHOEAE",

author = "{Van Dessel}, {Helke A.} and Dirks, {Jeanne A.M.C.} and {Van Loo}, {Inge H.M.} and {Van Der Veer}, {Brian M.J.W.} and Hoebe, {Christian J.P.A.} and Dukers-Muijrers, {Nicole H.T.M.} and Savelkoul, {Paul H.M.} and Petra Wolffs",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2023",

month = nov,

day = "29",

doi = "10.1136/sextrans-2023-055977",

language = "English",

volume = "100",

pages = "127--128",

journal = "Sexually Transmitted Infections",

issn = "1368-4973",

publisher = "BMJ Publishing Group",

number = "2",

}

Van Dessel, HA, Dirks, JAMC, Van Loo, IHM, Van Der Veer, BMJW, Hoebe, CJPA , Dukers-Muijrers, NHTM , Savelkoul, PHM & Wolffs, P 2023, 'Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms', Sexually Transmitted Infections, vol. 100, no. 2, pp. 127-128. https://doi.org/10.1136/sextrans-2023-055977

Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms. / Van Dessel, Helke A.; Dirks, Jeanne A.M.C.; Van Loo, Inge H.M. et al.
In: Sexually Transmitted Infections, Vol. 100, No. 2, 29.11.2023, p. 127-128.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms

AU - Van Dessel, Helke A.

AU - Dirks, Jeanne A.M.C.

AU - Van Loo, Inge H.M.

AU - Van Der Veer, Brian M.J.W.

AU - Hoebe, Christian J.P.A.

AU - Dukers-Muijrers, Nicole H.T.M.

AU - Savelkoul, Paul H.M.

AU - Wolffs, Petra

PY - 2023/11/29

Y1 - 2023/11/29

N2 - Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) coinfections are commonly reported; in high-risk groups up to 40% of those infected with NG are also infected with CT.1 While coinfections might happen accidentally, it has been mathematically proven that it occurs much more frequently than can be expected from random chance alone.2 However, little is known about the effect of coinfections on pathogenesis, bacterial load, transmission and disease severity. Prior studies in this field are scarce and with contradictory results.1 To address this knowledge gap we looked at the effect of NG/CT coinfections on the NG bacterial load, and how coinfections with CT influence symptom severity of NG infections.

AB - Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) coinfections are commonly reported; in high-risk groups up to 40% of those infected with NG are also infected with CT.1 While coinfections might happen accidentally, it has been mathematically proven that it occurs much more frequently than can be expected from random chance alone.2 However, little is known about the effect of coinfections on pathogenesis, bacterial load, transmission and disease severity. Prior studies in this field are scarce and with contradictory results.1 To address this knowledge gap we looked at the effect of NG/CT coinfections on the NG bacterial load, and how coinfections with CT influence symptom severity of NG infections.

KW - Bacterial Infections

KW - Chalmydia Trachomatis

KW - NEISSERIA GONORRHOEAE

U2 - 10.1136/sextrans-2023-055977

DO - 10.1136/sextrans-2023-055977

M3 - Comment/Letter to the editor

SN - 1368-4973

VL - 100

SP - 127

EP - 128

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

IS - 2

ER -

Van Dessel HA, Dirks JAMC, Van Loo IHM, Van Der Veer BMJW, Hoebe CJPA , Dukers-Muijrers NHTM et al. Higher Neisseria gonorrhoeae bacterial load in coinfections with Chlamydia trachomatis compared with Neisseria gonorrhoeae single infections does not lead to more symptoms. Sexually Transmitted Infections. 2023 Nov 29;100(2):127-128. Epub 2023 Jan 1. doi: 10.1136/sextrans-2023-055977