Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study

Ben M. Sorensen; Frank C. T. van der Heide; Alfons J. H. M. Houben; Annemarie Koster; Tos T. J. M. Berendschot; Jan S. A. G. Schouten; Abraham A. Kroon; Carla J. H. van der Kallen; Ronald M. A. Henry; Martien C. J. M. van Dongen; Simone J. P. M. Eussen; Hans H. C. M. Savelberg; Julianne D. van der Berg; Nicolaas C. Schaper; Miranda T. Schram; Coen D. A. Stehouwer

doi:10.1111/micc.12611

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study

Ben M. Sorensen, Frank C. T. van der Heide, Alfons J. H. M. Houben, Annemarie Koster, Tos T. J. M. Berendschot, Jan S. A. G. Schouten, Abraham A. Kroon, Carla J. H. van der Kallen, Ronald M. A. Henry, Martien C. J. M. van Dongen, Simone J. P. M. Eussen, Hans H. C. M. Savelberg, Julianne D. van der Berg, Nicolaas C. Schaper, Miranda T. Schram, Coen D. A. Stehouwer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.

Methods In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 +/- 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.

Results In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.

Conclusion Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

Original language	English
Article number	12611
Number of pages	13
Journal	Microcirculation
Volume	27
Issue number	4
DOIs	https://doi.org/10.1111/micc.12611
Publication status	Published - May 2020

Keywords

cohort studies
diabetes mellitus
type 2
exercise
microcirculation
sedentary behavior
FLOW-MEDIATED DILATION
NITRIC-OXIDE
BLOOD-FLOW
ENDOTHELIAL DYSFUNCTION
SEDENTARY BEHAVIOR
EXERCISE
INACTIVITY
REACTIVITY
PATHOLOGY
ARTERIAL

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Sorensen, B. M., van der Heide, F. C. T., Houben, A. J. H. M., Koster, A., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., van Dongen, M. C. J. M., Eussen, S. J. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2020). Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study. Microcirculation, 27(4), Article 12611. https://doi.org/10.1111/micc.12611

@article{c901dd5233ac4a0ca9d87fd89c2b6506,

title = "Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study",

abstract = "Objective Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.Methods In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 +/- 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.Results In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.Conclusion Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.",

keywords = "cohort studies, diabetes mellitus, type 2, exercise, microcirculation, sedentary behavior, FLOW-MEDIATED DILATION, NITRIC-OXIDE, BLOOD-FLOW, ENDOTHELIAL DYSFUNCTION, SEDENTARY BEHAVIOR, EXERCISE, INACTIVITY, REACTIVITY, PATHOLOGY, ARTERIAL",

author = "Sorensen, {Ben M.} and {van der Heide}, {Frank C. T.} and Houben, {Alfons J. H. M.} and Annemarie Koster and Berendschot, {Tos T. J. M.} and Schouten, {Jan S. A. G.} and Kroon, {Abraham A.} and {van der Kallen}, {Carla J. H.} and Henry, {Ronald M. A.} and {van Dongen}, {Martien C. J. M.} and Eussen, {Simone J. P. M.} and Savelberg, {Hans H. C. M.} and {van der Berg}, {Julianne D.} and Schaper, {Nicolaas C.} and Schram, {Miranda T.} and Stehouwer, {Coen D. A.}",

note = "Funding Information: This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (J{\"a}rf{\"a}lla, Sweden), Diabetesfonds (Amersfoort, The Netherlands) (grant 2016.22.1878), and Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen-Cilag BV (Tilburg, the Netherlands), Novo Nordisk Farma BV (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands BV (Gouda, the Netherlands). The authors would like to acknowledge ZIO foundation (Vereniging Regionale HuisartsenZorg Heuvelland) for their contribution to The Maastricht Study. The researchers are indebted to the participants for their willingness to participate in the study. Funding Information: This study was supported by the European Regional Development Fund via OP‐Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (J{\"a}rf{\"a}lla, Sweden), Diabetesfonds (Amersfoort, The Netherlands) (grant 2016.22.1878), and Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen‐Cilag BV (Tilburg, the Netherlands), Novo Nordisk Farma BV (Alphen aan den Rijn, the Netherlands), and Sanofi‐Aventis Netherlands BV (Gouda, the Netherlands). Publisher Copyright: {\textcopyright} 2020 The Authors. Microcirculation published by John Wiley & Sons Ltd",

year = "2020",

month = may,

doi = "10.1111/micc.12611",

language = "English",

volume = "27",

journal = "Microcirculation",

issn = "1073-9688",

publisher = "Wiley-Blackwell",

number = "4",

}

Sorensen, BM, van der Heide, FCT, Houben, AJHM , Koster, A , Berendschot, TTJM, Schouten, JSAG, Kroon, AA , van der Kallen, CJH , Henry, RMA, van Dongen, MCJM, Eussen, SJPM , Savelberg, HHCM, van der Berg, JD, Schaper, NC, Schram, MT & Stehouwer, CDA 2020, 'Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study', Microcirculation, vol. 27, no. 4, 12611. https://doi.org/10.1111/micc.12611

TY - JOUR

T1 - Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study

AU - Sorensen, Ben M.

AU - van der Heide, Frank C. T.

AU - Houben, Alfons J. H. M.

AU - Koster, Annemarie

AU - Berendschot, Tos T. J. M.

AU - Schouten, Jan S. A. G.

AU - Kroon, Abraham A.

AU - van der Kallen, Carla J. H.

AU - Henry, Ronald M. A.

AU - van Dongen, Martien C. J. M.

AU - Eussen, Simone J. P. M.

AU - Savelberg, Hans H. C. M.

AU - van der Berg, Julianne D.

AU - Schaper, Nicolaas C.

AU - Schram, Miranda T.

AU - Stehouwer, Coen D. A.

N1 - Funding Information: This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Järfälla, Sweden), Diabetesfonds (Amersfoort, The Netherlands) (grant 2016.22.1878), and Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen-Cilag BV (Tilburg, the Netherlands), Novo Nordisk Farma BV (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands BV (Gouda, the Netherlands). The authors would like to acknowledge ZIO foundation (Vereniging Regionale HuisartsenZorg Heuvelland) for their contribution to The Maastricht Study. The researchers are indebted to the participants for their willingness to participate in the study. Funding Information: This study was supported by the European Regional Development Fund via OP‐Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Järfälla, Sweden), Diabetesfonds (Amersfoort, The Netherlands) (grant 2016.22.1878), and Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen‐Cilag BV (Tilburg, the Netherlands), Novo Nordisk Farma BV (Alphen aan den Rijn, the Netherlands), and Sanofi‐Aventis Netherlands BV (Gouda, the Netherlands). Publisher Copyright: © 2020 The Authors. Microcirculation published by John Wiley & Sons Ltd

PY - 2020/5

Y1 - 2020/5

N2 - Objective Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.Methods In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 +/- 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.Results In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.Conclusion Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

AB - Objective Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.Methods In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 +/- 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.Results In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.Conclusion Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

KW - cohort studies

KW - diabetes mellitus

KW - type 2

KW - exercise

KW - microcirculation

KW - sedentary behavior

KW - FLOW-MEDIATED DILATION

KW - NITRIC-OXIDE

KW - BLOOD-FLOW

KW - ENDOTHELIAL DYSFUNCTION

KW - SEDENTARY BEHAVIOR

KW - EXERCISE

KW - INACTIVITY

KW - REACTIVITY

KW - PATHOLOGY

KW - ARTERIAL

U2 - 10.1111/micc.12611

DO - 10.1111/micc.12611

M3 - Article

C2 - 31997430

SN - 1073-9688

VL - 27

JO - Microcirculation

JF - Microcirculation

IS - 4

M1 - 12611

ER -