High-Sensitivity Troponin-T and Cardiovascular Outcomes in the Community: Differences Between Women and Men

Navin Suthahar*, Laura M. G. Meems, Dirk J. van Veldhuisen, Joan E. Walter, Ron T. Gansevoort, Stephane Heymans, Blanche Schroen, Pim van der Harst, Jenny E. Kootstra-Ros, Vanessa van Empel, Christian Mueller, Stephan J. L. Bakker, Rudolf A. de Boer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

Objective: To evaluate associations of high-sensitivity cardiac troponin-T (cTnT) with cardiovascular disease (CVD), heart failure (HF), and mortality in community-dwelling women and men. Participants and Methods: A total of 8226 adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) cohort (1997 e1998) were enrolled in a prospective observational study (mean age: 49 years; 50.2% women). Sex-speci fic associations of cTnT levels with future clinical outcomes were evaluated using adjusted Cox-regression models. Results: Measurable cTnT levels (3 ng/L) were detected in 1102 women (26.7%) and in 2396 men (58.5%). Baseline cTnT levels were associated with a greater risk of developing CVD in women than men [Hazard ratio (HRwomen), 1.48 per unit increase in log 2-cTnT; 95% CI, 1.21 to 1.81 vs HRmen, 1.20; 95% CI, 1.07 to 1.35; P-interaction <.001]. Similar sex-related differences were observed for HF (P interaction = .005) and mortality (P-interaction = .008). Further, compared with referent category (cTnT

Original languageEnglish
Pages (from-to)1158-1168
Number of pages11
JournalMayo Clinic Proceedings
Volume95
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • ONSET HEART-FAILURE
  • CARDIAC TROPONIN
  • NATRIURETIC PEPTIDE
  • PROGNOSTIC VALUE
  • ATRIAL-FIBRILLATION
  • SEX-DIFFERENCES
  • FOLLOW-UP
  • RISK
  • MORTALITY
  • EVENTS

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