TY - JOUR
T1 - High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition
T2 - the PRIME post-COVID study
AU - Pagen, Demi M. E.
AU - Van Herck, Maarten
AU - van Bilsen, Celine J. A.
AU - Brinkhues, Stephanie
AU - Konings, Kevin
AU - den Heijer, Casper D. J.
AU - Spruit, Martijn A.
AU - Hoebe, Christian J. P. A.
AU - Dukers-Muijrers, Nicole H. T. M.
PY - 2023/12/15
Y1 - 2023/12/15
N2 - BackgroundExercise-based treatments can worsen/exacerbate symptoms in people who were SARS-CoV-2 positive and living with post-COVID-19 condition (PL-PCC) and who have post-exertional malaise (PEM) or orthostatic intolerance (OI). Nevertheless, PEM and OI are not routinely assessed by clinicians. We estimated PEM and OI proportions in PL-PCC, as well as in people not living with PCC (PnL-PCC) and negatives (i.e., never reported a SARS-CoV-2 positive test), and identified associated factors.MethodsParticipants from the Prevalence, Risk factors, and Impact Evaluation (PRIME) post-COVID-19 condition study were included. PEM and OI were assessed using validated questionnaires. PCC was defined as feeling unrecovered after SARS-CoV-2 infection. Multivariable regression analyses to study PEM and OI were stratified for sex.ResultsData from 3,783 participants were analyzed. In PL-PCC, the proportion of PEM was 48.1% and 41.2%, and the proportion of OI was 29.3% and 27.9% in women and men, respectively. Proportions were higher in PL-PCC than negatives, for PEM in women OR=4.38 [95%CI:3.01-6.38]; in men OR = 4.78 [95%CI:3.13-7.29]; for OI in women 3.06 [95%CI:1.97-4.76]; in men 2.71 [95%CI:1.75-4.21]. Associated factors were age <= 60 years, >= 1 comorbidities, and living alone.ConclusionHigh proportions of PEM and OI are observed in PL-PCC. Standard screening for PEM and OI is recommended in PL-PCC to promote appropriate therapies.
AB - BackgroundExercise-based treatments can worsen/exacerbate symptoms in people who were SARS-CoV-2 positive and living with post-COVID-19 condition (PL-PCC) and who have post-exertional malaise (PEM) or orthostatic intolerance (OI). Nevertheless, PEM and OI are not routinely assessed by clinicians. We estimated PEM and OI proportions in PL-PCC, as well as in people not living with PCC (PnL-PCC) and negatives (i.e., never reported a SARS-CoV-2 positive test), and identified associated factors.MethodsParticipants from the Prevalence, Risk factors, and Impact Evaluation (PRIME) post-COVID-19 condition study were included. PEM and OI were assessed using validated questionnaires. PCC was defined as feeling unrecovered after SARS-CoV-2 infection. Multivariable regression analyses to study PEM and OI were stratified for sex.ResultsData from 3,783 participants were analyzed. In PL-PCC, the proportion of PEM was 48.1% and 41.2%, and the proportion of OI was 29.3% and 27.9% in women and men, respectively. Proportions were higher in PL-PCC than negatives, for PEM in women OR=4.38 [95%CI:3.01-6.38]; in men OR = 4.78 [95%CI:3.13-7.29]; for OI in women 3.06 [95%CI:1.97-4.76]; in men 2.71 [95%CI:1.75-4.21]. Associated factors were age <= 60 years, >= 1 comorbidities, and living alone.ConclusionHigh proportions of PEM and OI are observed in PL-PCC. Standard screening for PEM and OI is recommended in PL-PCC to promote appropriate therapies.
KW - COVID-19
KW - long COVID
KW - post-COVID-19 condition
KW - post-exertional malaise
KW - orthostatic intolerance
U2 - 10.3389/fmed.2023.1292446
DO - 10.3389/fmed.2023.1292446
M3 - Article
SN - 2296-858X
VL - 10
JO - Frontiers in medicine
JF - Frontiers in medicine
M1 - 1292446
ER -