TY - JOUR
T1 - Heart 'omics' in AGEing (HOMAGE)
T2 - design, research objectives and characteristics of the common database
AU - Jacobs, Lotte
AU - Thijs, Lutgarde
AU - Jin, Yu
AU - Zannad, Faiez
AU - Mebazaa, Alexandre
AU - Rouet, Philippe
AU - Pinet, Florence
AU - Bauters, Christophe
AU - Pieske, Burkert
AU - Tomaschitz, Andreas
AU - Mamas, Mamas
AU - Diez, Javier
AU - McDonald, Kenneth
AU - Cleland, John G F
AU - Brunner-La Rocca, Hans-Peter
AU - Heymans, Stephane
AU - Latini, Roberto
AU - Masson, Serge
AU - Sever, Peter
AU - Delles, Christian
AU - Pocock, Stuart
AU - Collier, Timothy
AU - Kuznetsova, Tatiana
AU - Staessen, Jan A
PY - 2014/9
Y1 - 2014/9
N2 - Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n = 7,124), patients with heart failure (n = 4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n = 31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
AB - Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n = 7,124), patients with heart failure (n = 4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n = 31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
U2 - 10.7555/JBR.28.20140045
DO - 10.7555/JBR.28.20140045
M3 - Article
C2 - 25332706
SN - 1674-8301
VL - 28
SP - 349
EP - 359
JO - Journal of Biomedical Research
JF - Journal of Biomedical Research
IS - 5
ER -