Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Arnau Vich Vila, Floris Imhann, Valerie Collij, Soesma A. Jankipersadsing, Thomas Gurry, Zlatan Mujagic, Alexander Kurilshikov, Marc Jan Bonder, Xiaofang Jiang, Ettje F. Tigchelaar, Jackie Dekens, Vera Peters, Michiel D. Voskuil, Marijn C. Visschedijk, Hendrik M. van Dullemen, Daniel Keszthelyi, Morris A. Swertz, Lude Franke, Rudi Alberts, Eleonora A. M. FestenGerard Dijkstra, Ad A. M. Masclee, Marten H. Hofker, Ramnik J. Xavier, Eric J. Alm, Jingyuan Fu, Cisca Wijmenga Section, Daisy M. A. E. Jonkers Section, Alexandra Zhernakova, Rinse K. Weersma*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.

Original languageEnglish
Article number8914
Number of pages11
JournalScience Translational Medicine
Issue number472
Publication statusPublished - 19 Dec 2018


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