Graph analysis of EEG resting state functional networks in dyslexic readers

G Fraga González, M J W Van der Molen, Gojko Žarić , M Bonte, J Tijms, L Blomert, C J Stam, M W Van der Molen

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
186 Downloads (Pure)

Abstract

OBJECTIVE: Neuroimaging research suggested a mixed pattern of functional connectivity abnormalities in developmental dyslexia. We examined differences in the topological properties of functional networks between 29 dyslexics and 15 typically reading controls in 3rd grade using graph analysis. Graph metrics characterize brain networks in terms of integration and segregation.

METHOD: We used EEG resting-state data and calculated weighted connectivity matrices for multiple frequency bands using the phase lag index (PLI). From the connectivity matrices we derived minimum spanning tree (MST) graphs representing the sub-networks with maximum connectivity. Statistical analyses were performed on graph-derived metrics as well as on the averaged PLI connectivity values.

RESULTS: We found group differences in the theta band for two graph metrics suggesting reduced network integration and communication between network nodes in dyslexics compared to controls.

CONCLUSION: Collectively, our findings point to a less efficient network configuration in dyslexics relative to the more proficient configuration in the control group.

SIGNIFICANCE: Graph metrics relate to the intrinsic organization of functional brain networks. These metrics provide additional insights on the cognitive deficits underlying dyslexia and, thus, may advance our knowledge on reading development. Our findings add to the growing body literature suggesting compromised networks rather than specific dysfunctional brain regions in dyslexia.

Original languageEnglish
Pages (from-to)3165-3175
Number of pages11
JournalClinical Neurophysiology
Volume127
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Electroencephalography (EEG)
  • Functional connectivity
  • Network
  • Graph theory
  • Minimum spanning tree
  • Dyslexia
  • MINIMUM SPANNING TREE
  • COMPLEX BRAIN NETWORKS
  • THEORETICAL ANALYSIS
  • FMRI CONNECTIVITY
  • NEURAL SYSTEMS
  • CHILDREN
  • TASK
  • ORGANIZATION
  • DISRUPTION
  • OSCILLATIONS

Research Output

  • 5 Citations
  • 1 Erratum / corrigendum

Corrigendum to "Graph analysis of EEG resting state functional networks in dyslexic readers" [Clin. Neurophysiol. 127(9) (2016) 3165–3175]

Gonzalez, G. F., van der Molen, M. J. W., Zaric, G., Bonte, M., Tijms, J., Blomert, L., Stam, C. J. & Van der Molen, M. W., Jan 2018, In : Clinical Neurophysiology. 129, 1, p. 339-340 2 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Cite this

Fraga González, G., Van der Molen, M. J. W., Žarić , G., Bonte, M., Tijms, J., Blomert, L., Stam, C. J., & Van der Molen, M. W. (2016). Graph analysis of EEG resting state functional networks in dyslexic readers. Clinical Neurophysiology, 127(9), 3165-3175. https://doi.org/10.1016/j.clinph.2016.06.023