Abstract
The object recognition and to a lesser extent the object location tests contributed to the better understanding of the role of glutamatergic signalling in memory. Pharmacological manipulation of glutamate signalling showed that its different components contribute to distinct stages of memory formation. Additionally positive modulation of glutamate transmission was shown to facilitate storage of object recognition memory, while its inhibition could be neuroprotective against excitotoxicity.
Original language | English |
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Title of host publication | Handbook of Object Novelty Recognition |
Editors | Abdel Ennaceur, Maria Angelica de Souza Silva |
Publisher | Elsevier |
Pages | 541-551 |
Number of pages | 11 |
Volume | 27 |
ISBN (Print) | 978-0-12-812012-5 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- Ionotropic glutamate receptors
- Metabotropic glutamate receptors