Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

A. Shami, D. Atzler, L.A. Bosmans, H. Winkels, S. Meiler, M. Lacy, C. van Tiel, R.T. Megens, K. Nitz, J. Baardman, P. Kusters, T. Seijkens, C. Buerger, A. Janjic, C. Riccardi, A. Edsfeldt, C. Monaco, M. Daemen, M.P.J. de Winther, J. NilssonC. Weber, N. Gerdes, I. Goncalves, E. Lutgens

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2938-2948
Number of pages13
JournalEuropean Heart Journal
Volume41
Issue number31
DOIs
Publication statusPublished - 14 Aug 2020

Keywords

  • activation
  • atherosclerosis
  • carotid artery
  • co-stimulation
  • effector
  • expression
  • gitr
  • ligand
  • macrophages
  • monocyte
  • monocytes
  • peripheral-blood
  • reduces atherosclerosis
  • regulatory t-cells
  • stimulation
  • GITR
  • ACTIVATION
  • Co-stimulation
  • PERIPHERAL-BLOOD
  • Atherosclerosis
  • REGULATORY T-CELLS
  • Carotid artery
  • LIGAND
  • STIMULATION
  • Monocyte
  • MACROPHAGES
  • MONOCYTES
  • EFFECTOR
  • REDUCES ATHEROSCLEROSIS
  • EXPRESSION

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