Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

Maria Trojano; Guglielmo Lucchese; Giusi Graziano; Bruce V. Taylor; Steve, Jr. Simpson; Vito Lepore; Francois Grand'Maison; Pierre Duquette; Guillermo Izquierdo; Pierre Grammond; Maria Pia Amato; Roberto Bergamaschi; Giorgio Giuliani; Cavit Boz; Raymond Hupperts; Vincent Van Pesch; Jeannette Lechner-Scott; Edgardo Cristiano; Marcela Fiol; Celia Oreja-Guevara; Maria Laura Saladino; Freek Verheul; Mark Slee; Damiano Paolicelli; Carla Tortorella; Mariangela D'Onghia; Pietro Iaffaldano; Vita Direnzo; Helmut Butzkueven

doi:10.1371/journal.pone.0048078

Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

Maria Trojano^*, Guglielmo Lucchese, Giusi Graziano, Bruce V. Taylor, Steve, Jr. Simpson, Vito Lepore, Francois Grand'Maison, Pierre Duquette, Guillermo Izquierdo, Pierre Grammond, Maria Pia Amato, Roberto Bergamaschi, Giorgio Giuliani, Cavit Boz, Raymond Hupperts, Vincent Van Pesch, Jeannette Lechner-Scott, Edgardo Cristiano, Marcela Fiol, Celia Oreja-GuevaraMaria Laura Saladino, Freek Verheul, Mark Slee, Damiano Paolicelli, Carla Tortorella, Mariangela D'Onghia, Pietro Iaffaldano, Vita Direnzo, Helmut Butzkueven

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out.In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas.Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births.Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83? N and 45? N (from 1.93 to 4.55; p

Original language	English
Article number	e48078
Journal	PLOS ONE
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0048078
Publication status	Published - 25 Oct 2012

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Trojano, M., Lucchese, G., Graziano, G., Taylor, B. V., Simpson, S. J., Lepore, V., Grand'Maison, F., Duquette, P., Izquierdo, G., Grammond, P., Amato, M. P., Bergamaschi, R., Giuliani, G., Boz, C., Hupperts, R., Van Pesch, V., Lechner-Scott, J., Cristiano, E., Fiol, M., ... Butzkueven, H. (2012). Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis. PLOS ONE, 7(10), Article e48078. https://doi.org/10.1371/journal.pone.0048078

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title = "Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis",

abstract = "A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out.In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas.Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births.Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83? N and 45? N (from 1.93 to 4.55; p",

author = "Maria Trojano and Guglielmo Lucchese and Giusi Graziano and Taylor, {Bruce V.} and Simpson, {Steve, Jr.} and Vito Lepore and Francois Grand'Maison and Pierre Duquette and Guillermo Izquierdo and Pierre Grammond and Amato, {Maria Pia} and Roberto Bergamaschi and Giorgio Giuliani and Cavit Boz and Raymond Hupperts and {Van Pesch}, Vincent and Jeannette Lechner-Scott and Edgardo Cristiano and Marcela Fiol and Celia Oreja-Guevara and {Laura Saladino}, Maria and Freek Verheul and Mark Slee and Damiano Paolicelli and Carla Tortorella and Mariangela D'Onghia and Pietro Iaffaldano and Vita Direnzo and Helmut Butzkueven",

year = "2012",

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doi = "10.1371/journal.pone.0048078",

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Trojano, M, Lucchese, G, Graziano, G, Taylor, BV, Simpson, SJ, Lepore, V, Grand'Maison, F, Duquette, P, Izquierdo, G, Grammond, P, Amato, MP, Bergamaschi, R, Giuliani, G, Boz, C, Hupperts, R, Van Pesch, V, Lechner-Scott, J, Cristiano, E, Fiol, M, Oreja-Guevara, C, Laura Saladino, M, Verheul, F, Slee, M, Paolicelli, D, Tortorella, C, D'Onghia, M, Iaffaldano, P, Direnzo, V & Butzkueven, H 2012, 'Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis', PLOS ONE, vol. 7, no. 10, e48078. https://doi.org/10.1371/journal.pone.0048078

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T1 - Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

AU - Trojano, Maria

AU - Lucchese, Guglielmo

AU - Graziano, Giusi

AU - Taylor, Bruce V.

AU - Simpson, Steve, Jr.

AU - Lepore, Vito

AU - Grand'Maison, Francois

AU - Duquette, Pierre

AU - Izquierdo, Guillermo

AU - Grammond, Pierre

AU - Amato, Maria Pia

AU - Bergamaschi, Roberto

AU - Giuliani, Giorgio

AU - Boz, Cavit

AU - Hupperts, Raymond

AU - Van Pesch, Vincent

AU - Lechner-Scott, Jeannette

AU - Cristiano, Edgardo

AU - Fiol, Marcela

AU - Oreja-Guevara, Celia

AU - Laura Saladino, Maria

AU - Verheul, Freek

AU - Slee, Mark

AU - Paolicelli, Damiano

AU - Tortorella, Carla

AU - D'Onghia, Mariangela

AU - Iaffaldano, Pietro

AU - Direnzo, Vita

AU - Butzkueven, Helmut

PY - 2012/10/25

Y1 - 2012/10/25

N2 - A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out.In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas.Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births.Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83? N and 45? N (from 1.93 to 4.55; p

AB - A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out.In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas.Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births.Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83? N and 45? N (from 1.93 to 4.55; p

U2 - 10.1371/journal.pone.0048078

DO - 10.1371/journal.pone.0048078

M3 - Article

C2 - 23133550

SN - 1932-6203

VL - 7

JO - PLOS ONE

JF - PLOS ONE

IS - 10

M1 - e48078

ER -

Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

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