Abstract
Genetic basis of drug-induced arrhythmias.
Vos MA, Paulussen AD.
Department of Medical Physiology, University Medical Center Utrecht, The Netherlands. [email protected]
Drug-induced torsade de pointes arrhythmia (TdP) is frequently seen in patients. This proarrhythmia is not restricted to anti-arrhythmics but includes a variety of drugs. A genetic predisposition is an attractive explanation for this clinical problem. In this review, we: 1) explain the arrhythmogenic mechanisms of TdP, 2) provide data for a genetic cause based upon mutations in the long QT or in cytochrome genes responsible for drug metabolism, and 3) present pathology-based electrical remodeling as an alternative explanation. It can be concluded that the current evidence for a genetic basis for drug-induced TdP is weak
Vos MA, Paulussen AD.
Department of Medical Physiology, University Medical Center Utrecht, The Netherlands. [email protected]
Drug-induced torsade de pointes arrhythmia (TdP) is frequently seen in patients. This proarrhythmia is not restricted to anti-arrhythmics but includes a variety of drugs. A genetic predisposition is an attractive explanation for this clinical problem. In this review, we: 1) explain the arrhythmogenic mechanisms of TdP, 2) provide data for a genetic cause based upon mutations in the long QT or in cytochrome genes responsible for drug metabolism, and 3) present pathology-based electrical remodeling as an alternative explanation. It can be concluded that the current evidence for a genetic basis for drug-induced TdP is weak
| Original language | English |
|---|---|
| Pages (from-to) | 35-40 |
| Journal | Annals of Medicine |
| Volume | 36 |
| Issue number | Suppl 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2004 |