Genetic association study of the P300 endophenotype in schizophrenia

Jeroen Decoster; Marc De Hert; Wolfgang Viechtbauer; Guy Nagels; Inez Myin-Germeys; Jos Peuskens; Jim van Os; Ruud van Winkel

doi:10.1016/j.schres.2012.07.018

Genetic association study of the P300 endophenotype in schizophrenia

Jeroen Decoster, Marc De Hert, Wolfgang Viechtbauer, Guy Nagels, Inez Myin-Germeys, Jos Peuskens, Jim van Os, Ruud van Winkel^*

^*Corresponding author for this work

MHeNs School for Mental Health and Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: Although reduced amplitude of the P300 event-related potential is a well-documented intermediate phenotype of schizophrenia, little is known about its genetic underpinnings in patients with schizophrenia. This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia. Methods: P300 amplitude at the midline parietal electrode and 193 single nucleotide polymorphisms (SNPs) in 67 genes were assessed in 336 patients with schizophrenia. The association between each SNP and P300 amplitude, controlled for illness duration and gender, was evaluated. Associations at p

Original language	English
Pages (from-to)	54-59
Journal	Schizophrenia Research
Volume	141
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2012.07.018
Publication status	Published - Oct 2012

Keywords

Schizophrenia
P300
Event-related potential (ERP)
ABCB1-gene
P-glycoprotein
Intermediate phenotype

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10.1016/j.schres.2012.07.018

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Cite this

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title = "Genetic association study of the P300 endophenotype in schizophrenia",

abstract = "Objective: Although reduced amplitude of the P300 event-related potential is a well-documented intermediate phenotype of schizophrenia, little is known about its genetic underpinnings in patients with schizophrenia. This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia. Methods: P300 amplitude at the midline parietal electrode and 193 single nucleotide polymorphisms (SNPs) in 67 genes were assessed in 336 patients with schizophrenia. The association between each SNP and P300 amplitude, controlled for illness duration and gender, was evaluated. Associations at p",

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AU - Decoster, Jeroen

AU - De Hert, Marc

AU - Viechtbauer, Wolfgang

AU - Nagels, Guy

AU - Myin-Germeys, Inez

AU - Peuskens, Jos

AU - van Os, Jim

AU - van Winkel, Ruud

PY - 2012/10

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N2 - Objective: Although reduced amplitude of the P300 event-related potential is a well-documented intermediate phenotype of schizophrenia, little is known about its genetic underpinnings in patients with schizophrenia. This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia. Methods: P300 amplitude at the midline parietal electrode and 193 single nucleotide polymorphisms (SNPs) in 67 genes were assessed in 336 patients with schizophrenia. The association between each SNP and P300 amplitude, controlled for illness duration and gender, was evaluated. Associations at p

AB - Objective: Although reduced amplitude of the P300 event-related potential is a well-documented intermediate phenotype of schizophrenia, little is known about its genetic underpinnings in patients with schizophrenia. This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia. Methods: P300 amplitude at the midline parietal electrode and 193 single nucleotide polymorphisms (SNPs) in 67 genes were assessed in 336 patients with schizophrenia. The association between each SNP and P300 amplitude, controlled for illness duration and gender, was evaluated. Associations at p

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KW - Event-related potential (ERP)

KW - ABCB1-gene

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