Genetic association study of the P300 endophenotype in schizophrenia

Jeroen Decoster, Marc De Hert, Wolfgang Viechtbauer, Guy Nagels, Inez Myin-Germeys, Jos Peuskens, Jim van Os, Ruud van Winkel*

*Corresponding author for this work

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Abstract

Objective: Although reduced amplitude of the P300 event-related potential is a well-documented intermediate phenotype of schizophrenia, little is known about its genetic underpinnings in patients with schizophrenia. This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia. Methods: P300 amplitude at the midline parietal electrode and 193 single nucleotide polymorphisms (SNPs) in 67 genes were assessed in 336 patients with schizophrenia. The association between each SNP and P300 amplitude, controlled for illness duration and gender, was evaluated. Associations at p
Original languageEnglish
Pages (from-to)54-59
JournalSchizophrenia Research
Volume141
Issue number1
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Schizophrenia
  • P300
  • Event-related potential (ERP)
  • ABCB1-gene
  • P-glycoprotein
  • Intermediate phenotype

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