@article{4e3d512d52e84cacbcf62570c022a739,
title = "Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding",
abstract = "The present study examines whether neuroticism is predicted by genetic vulnerability, summarized as polygenic risk score for neuroticism (PRSN), in interaction with bullying, parental bonding, and childhood adversity. Data were derived from a general population adolescent and young adult twin cohort. The final sample consisted of 202 monozygotic and 436 dizygotic twins and 319 twin pairs. The Short Eysenck Personality questionnaire was used to measure neuroticism. PRSN was trained on the results from the Genetics of Personality Consortium (GPC) and United Kingdom Biobank (UKB) cohorts, yielding two different PRSN. Multilevel mixed-effects models were used to analyze the main and interacting associations of PRSN, childhood adversity, bullying, and parental bonding style with neuroticism. We found no evidence of gene-environment correlation. PRSN thresholds of.005 and.2 were chosen, based on GPC and UKB datasets, respectively. After correction for confounders, all the individual variables were associated with the expression of neuroticism: both PRSN from GPC and UKB, childhood adversity, maternal bonding, paternal bonding, and bullying in primary school and secondary school. However, the results indicated no evidence for gene-environment interaction in this cohort. These results suggest that genetic vulnerability on the one hand and negative life events (childhood adversity and bullying) and positive life events (optimal parental bonding) on the other represent noninteracting pathways to neuroticism.",
keywords = "Endophenotype, Environment, Genetics, Neuroticism, Personality",
author = "Boris Klingenberg and Sinan Guloksuz and Pries, {Lotta Katrin} and Ozan Cinar and Claudia Menne-Lothmann and Jeroen Decoster and {Van Winkel}, Ruud and Dina Collip and Philippe Delespaul and {De Hert}, Marc and Catherine Derom and Evert Thiery and Nele Jacobs and Marieke Wichers and Lin, {Bochao D.} and Jurjen Luykx and {Van Os}, Jim and Rutten, {Bart P.F.}",
note = "Funding Information: The authors would like to acknowledge that the East Flanders Prospective Twin Survey (EFPTS) is partly supported by the Association for Scientific Research in Multiple Births and that the TwinssCan project is part of the European Community{\textquoteright}s Seventh Framework Program under grant agreement HEALTH-F2-2009-241909 (Project EU-GEI). B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization. S. Guloksuz and B. Rutten are supported by the YOUTH-GEMs project, funded by the European Union{\textquoteright}s Horizon Europe program under the grant agreement number: 101057182. Funding Information: The authors would like to acknowledge that the East Flanders Prospective Twin Survey (EFPTS) is partly supported by the Association for Scientific Research in Multiple Births and that the TwinssCan project is part of the European Community's Seventh Framework Program under grant agreement HEALTH-F2-2009-241909 (Project EU-GEI). B.P.F. Rutten was funded by a VIDI award (no. 91718336) from the Netherlands Scientific Organization. S. Guloksuz and B. Rutten are supported by the YOUTH-GEMs project, funded by the European Union's Horizon Europe program under the grant agreement number: 101057182. Publisher Copyright: {\textcopyright} The Author(s), 2023. Published by Cambridge University Press.",
year = "2023",
month = aug,
day = "4",
doi = "10.1017/pen.2023.2",
language = "English",
volume = "6",
journal = "Personality neuroscience",
issn = "2513-9886",
publisher = "Cambridge University Press",
}