Functional MRI in Peripheral Arterial Disease: Arterial Peak Flow versus Ankle-Brachial Index

B. Versluis, P.J. Nelemans, R. Brans, J.E. Wildberger, G.W. Schurink, T. Leiner, W.H. Backes

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: The purpose of this study was to compare the success rate of successful arterial peak flow (APF) and ankle-brachial index (ABI) measurements in patients with suspected or known peripheral arterial disease (PAD).

Materials and Methods: 183 patients with varying degrees of PAD were included. All subjects underwent ABI measurements and MR imaging of the popliteal artery to determine APF. Proportions of patients with successful APF and ABI measurements were compared and the discriminative capability was evaluated.

Results: APF was successfully measured in 91% of the patients, whereas the ABI could be determined in 71% of the patients (p

Conclusions: Compared to the assessment of PAD severity with ABI, the success rate of MRI-based APF measurements in patients with a clinical indication for MRA is 20% higher, with similar discriminatory capacity for disease severity. Therefore, APF is an especially convenient and valuable measure to assess severity in PAD patients scheduled to undergo MR angiography to obtain additional functional information concerning the vascular status.

Original languageEnglish
Article numbere88471
Number of pages6
JournalPLOS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 5 Feb 2014

Keywords

  • LOWER-EXTREMITY
  • PRESSURE INDEX
  • ALL-CAUSE
  • SENSITIVITY
  • ANGIOGRAPHY
  • MANAGEMENT
  • QUANTIFICATION
  • CALCIFICATION
  • SPECIFICITY
  • GUIDELINES

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