From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report

Rutger J Slegers; Jan Beckervordersandforth; Ann Hoeben; Govert Hoogland; Martijn P G Broen; Monique Anten; Jim T A Dings; Piet van den Ende; Wouter J P Henneman; Olaf E M G Schijns

doi:10.25259/SNI_1153_2021

From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report

Rutger J Slegers^*, Jan Beckervordersandforth, Ann Hoeben, Govert Hoogland, Martijn P G Broen, Monique Anten, Jim T A Dings, Piet van den Ende, Wouter J P Henneman, Olaf E M G Schijns

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET) belong to the group of low-grade epilepsy-associated tumors (LEAT) and are the most prevalent tumor types found in patients undergoing epilepsy surgery. Histopathological differentiation between GG and DNET can be difficult on biopsies due to limited tumor tissue.

Case Description: Here, we present a rare case where a low-grade tumor was initially classified as DNET, based on biopsy findings and unfortunately dedifferentiated within 10 years into a glioblastoma multiforme. After gross total resection, the initial tumor was reclassified as GG.

Conclusion: This case illustrates the diagnostic challenges of LEAT, especially on biopsy material. Therefore, we advocate to counsel for complete resection and histopathological diagnosis utilizing tumor markers to confirm the nature of the tumor and to advice type of follow-up and eventual concurrent treatment.

Original language	English
Article number	43
Number of pages	5
Journal	Surgical Neurology International
Volume	13
DOIs	https://doi.org/10.25259/SNI_1153_2021
Publication status	Published - 2022

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10.25259/SNI_1153_2021Licence: CC BY-NC-SA

Cite this

Slegers, R. J., Beckervordersandforth, J., Hoeben, A., Hoogland, G., Broen, M. P. G., Anten, M., Dings, J. T. A., van den Ende, P., Henneman, W. J. P., & Schijns, O. E. M. G. (2022). From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report. Surgical Neurology International, 13, Article 43. https://doi.org/10.25259/SNI_1153_2021

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title = "From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report",

abstract = "Background: Ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET) belong to the group of low-grade epilepsy-associated tumors (LEAT) and are the most prevalent tumor types found in patients undergoing epilepsy surgery. Histopathological differentiation between GG and DNET can be difficult on biopsies due to limited tumor tissue.Case Description: Here, we present a rare case where a low-grade tumor was initially classified as DNET, based on biopsy findings and unfortunately dedifferentiated within 10 years into a glioblastoma multiforme. After gross total resection, the initial tumor was reclassified as GG.Conclusion: This case illustrates the diagnostic challenges of LEAT, especially on biopsy material. Therefore, we advocate to counsel for complete resection and histopathological diagnosis utilizing tumor markers to confirm the nature of the tumor and to advice type of follow-up and eventual concurrent treatment.",

author = "Slegers, {Rutger J} and Jan Beckervordersandforth and Ann Hoeben and Govert Hoogland and Broen, {Martijn P G} and Monique Anten and Dings, {Jim T A} and {van den Ende}, Piet and Henneman, {Wouter J P} and Schijns, {Olaf E M G}",

note = "Copyright: {\textcopyright} 2022 Surgical Neurology International.",

year = "2022",

doi = "10.25259/SNI_1153_2021",

language = "English",

volume = "13",

journal = "Surgical Neurology International",

issn = "2229-5097",

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Slegers, RJ , Beckervordersandforth, J , Hoeben, A , Hoogland, G , Broen, MPG , Anten, M , Dings, JTA , van den Ende, P , Henneman, WJP & Schijns, OEMG 2022, 'From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report', Surgical Neurology International, vol. 13, 43. https://doi.org/10.25259/SNI_1153_2021

TY - JOUR

T1 - From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme

T2 - Pitfalls of initial diagnosis on biopsy material, a case report

AU - Slegers, Rutger J

AU - Beckervordersandforth, Jan

AU - Hoeben, Ann

AU - Hoogland, Govert

AU - Broen, Martijn P G

AU - Anten, Monique

AU - Dings, Jim T A

AU - van den Ende, Piet

AU - Henneman, Wouter J P

AU - Schijns, Olaf E M G

PY - 2022

Y1 - 2022

N2 - Background: Ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET) belong to the group of low-grade epilepsy-associated tumors (LEAT) and are the most prevalent tumor types found in patients undergoing epilepsy surgery. Histopathological differentiation between GG and DNET can be difficult on biopsies due to limited tumor tissue.Case Description: Here, we present a rare case where a low-grade tumor was initially classified as DNET, based on biopsy findings and unfortunately dedifferentiated within 10 years into a glioblastoma multiforme. After gross total resection, the initial tumor was reclassified as GG.Conclusion: This case illustrates the diagnostic challenges of LEAT, especially on biopsy material. Therefore, we advocate to counsel for complete resection and histopathological diagnosis utilizing tumor markers to confirm the nature of the tumor and to advice type of follow-up and eventual concurrent treatment.

AB - Background: Ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET) belong to the group of low-grade epilepsy-associated tumors (LEAT) and are the most prevalent tumor types found in patients undergoing epilepsy surgery. Histopathological differentiation between GG and DNET can be difficult on biopsies due to limited tumor tissue.Case Description: Here, we present a rare case where a low-grade tumor was initially classified as DNET, based on biopsy findings and unfortunately dedifferentiated within 10 years into a glioblastoma multiforme. After gross total resection, the initial tumor was reclassified as GG.Conclusion: This case illustrates the diagnostic challenges of LEAT, especially on biopsy material. Therefore, we advocate to counsel for complete resection and histopathological diagnosis utilizing tumor markers to confirm the nature of the tumor and to advice type of follow-up and eventual concurrent treatment.

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DO - 10.25259/SNI_1153_2021

M3 - Article

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SN - 2229-5097

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JO - Surgical Neurology International

JF - Surgical Neurology International

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