TY - JOUR
T1 - Frailty Screening is Associated with Hospitalization and Decline in Quality of Life and Functional Status in Older Patients with Inflammatory Bowel Disease
AU - Asscher, Vera E R
AU - Rodriguez Girondo, Mar D M
AU - Fens, J
AU - Waars, Sanne N
AU - Stuyt, Rogier J L
AU - Baven-Pronk, A Martine C
AU - Srivastava, Nidhi
AU - Jacobs, Rutger J
AU - Haans, Jeoffrey J L
AU - Meijer, Lennart J
AU - Klijnsma-Slagboom, Jacqueline D
AU - Duin, Marijn H
AU - Peters, Milou E R
AU - Lee-Kong, Felicia V Y L
AU - Provoost, Nanda E
AU - Tijdeman, Femke
AU - van Dijk, Kenan T
AU - Wieland, Monse W M
AU - Verstegen, Mirre G M
AU - van der Meijs, Melissa E
AU - Maan, Annemijn D I
AU - van Deudekom, Floor J
AU - van der Meulen-de Jong, Andrea E
AU - Mooijaart, Simon P
AU - Maljaars, P W Jeroen
PY - 2023/10
Y1 - 2023/10
N2 - BACKGROUND AND AIMS: To study frailty screening in association with hospitalization and decline in quality of life (QoL) and functional status in older patients with Inflammatory Bowel Diseases (IBD). METHODS: A prospective multicentre cohort study in IBD patients =65 years using frailty screening (G8 Questionnaire). Outcomes were all-cause, acute and IBD-related hospitalization, any infection, any malignancy, QoL (EQ5D-3L) and functional decline (Instrumental Activities of Daily Living, (IADL)) during 18 months follow-up. Confounders: age, IBD type, biochemical disease activity (C-reactive protein =10 mg/L and/or fecal calprotectin =250 µg/g), comorbidity (Charlson Comorbidity Index). RESULTS: Out of 405 patients, median age 70 years, 196 (48%) screened at risk for frailty. All-cause hospitalizations occurred 136 times in 96 patients (23.7%), acute hospitalizations 103 times in 74 (18.3%). Risk of frailty did not associate with all-cause (aHR 1.5, 95% CI 0.9-2.4), but did associate with acute hospitalizations (aHR 2.2, 95% CI 1.3-3.8). Infections occurred in 86 patients (21.2%) and were not associated with frailty. Decline in QoL was experienced by 108 (30.6%) patients, decline in functional status by 46 (13.3%). Frailty screening associated with decline in QoL (aOR 2.1, 95% CI 1.3-3.6) and functional status (aOR 3.7, 95% CI 1.7-8.1). CONCLUSIONS: Frailty screening associates with worse health outcomes in older patients with IBD. Further studies are needed to assess feasibility and effectiveness of implementation in routine care.
AB - BACKGROUND AND AIMS: To study frailty screening in association with hospitalization and decline in quality of life (QoL) and functional status in older patients with Inflammatory Bowel Diseases (IBD). METHODS: A prospective multicentre cohort study in IBD patients =65 years using frailty screening (G8 Questionnaire). Outcomes were all-cause, acute and IBD-related hospitalization, any infection, any malignancy, QoL (EQ5D-3L) and functional decline (Instrumental Activities of Daily Living, (IADL)) during 18 months follow-up. Confounders: age, IBD type, biochemical disease activity (C-reactive protein =10 mg/L and/or fecal calprotectin =250 µg/g), comorbidity (Charlson Comorbidity Index). RESULTS: Out of 405 patients, median age 70 years, 196 (48%) screened at risk for frailty. All-cause hospitalizations occurred 136 times in 96 patients (23.7%), acute hospitalizations 103 times in 74 (18.3%). Risk of frailty did not associate with all-cause (aHR 1.5, 95% CI 0.9-2.4), but did associate with acute hospitalizations (aHR 2.2, 95% CI 1.3-3.8). Infections occurred in 86 patients (21.2%) and were not associated with frailty. Decline in QoL was experienced by 108 (30.6%) patients, decline in functional status by 46 (13.3%). Frailty screening associated with decline in QoL (aOR 2.1, 95% CI 1.3-3.6) and functional status (aOR 3.7, 95% CI 1.7-8.1). CONCLUSIONS: Frailty screening associates with worse health outcomes in older patients with IBD. Further studies are needed to assess feasibility and effectiveness of implementation in routine care.
KW - Crohn’s disease
KW - elderly
KW - functional decline
KW - geriatric screening
KW - ulcerative colitis
U2 - 10.1093/ecco-jcc/jjad175
DO - 10.1093/ecco-jcc/jjad175
M3 - Article
SN - 1873-9946
JO - Journal of Crohn's & Colitis
JF - Journal of Crohn's & Colitis
M1 - jjad175
ER -