Fracture Patterns in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review of Recent Literature

V. Van Hulten, N. Rasmussen, J.H.M. Driessen, A.M. Burden, A. Kvist, J.P. van den Bergh*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

1 Citation (Web of Science)

Abstract

Purpose of Review In this narrative review, we have summarized the literature on fracture risk in T1DM and T2DM with a special focus on fracture site, time patterns, glucose-lowering drugs, and micro- and macrovascular complications. Recent Findings T1DM and T2DM were associated with an overall increased fracture risk, with preferent locations at the hip, vertebrae, humerus, and ankle in T1DM and at the hip, vertebrae, and likely humerus, distal forearm, and foot in T2DM. Fracture risk was higher with longer diabetes duration and the presence of micro- and macrovascular complications. In T2DM, fracture risk was higher with use of insulin, sulfonylurea, and thiazolidinediones and lower with metformin use. The increased fracture risk in T1DM and T2DM concerns specific fracture sites, and is higher in subjects with longer diabetes duration, vascular complications, and in T2DM with the use of specific glucose-lowering medication.
Original languageEnglish
Pages (from-to)644-655
Number of pages12
JournalCurrent Osteoporosis Reports
Volume19
Issue number6
Early online date1 Dec 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Diabetes mellitus
  • Fracture risk
  • Glucose-lowering medication
  • Micro- and macrovascular complications
  • FALL-RELATED INJURIES
  • BONE-MINERAL DENSITY
  • VERTEBRAL FRACTURES
  • INCREASED RISK
  • HIP-FRACTURES
  • METAANALYSIS
  • ASSOCIATION
  • POPULATION
  • PREVALENCE
  • OBESITY

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