Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and its Correlation with Visual Acuity in Asian Indian Premature Infants in their First Year of Life

Chaitra Jayadev, Anand Vinekar*, Shwetha Mangalesh, Mathew Kurian Kummelil, Anupama Kiran Kumar, Vasudha Kemmanu, Munusamy Sivakumar, Padmamalini Mahendradas, Kavitha Avadhani, Noel Bauer, Carroll A. B. Webers, Bhujang Shetty

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Purpose: To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants.

Methods: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards. The study cohort was divided into three groups based on the corrected age, 3-

Results: The mean visual acuity of the three groups was 1.60, 1.63, and 1.23 logMAR, respectively (p <0.001). Visual acuity significantly correlated with all four layers (IRL fusion, ELM, EZ, and OS-RPE in the 3-

Conclusions: The study provides insights into our understanding of a premature infant's foveal maturation in the first year. Inner retinal fusion or maturation is the most important event that correlates with better visual acuity throughout the first year. In addition, between 9 and 12 months PMA, the completion of the EZ at the foveal center positively influenced visual acuity. The presence of ROP did not influence development of the layers, but the sample size was small for subgroup analysis.

Original languageEnglish
Pages (from-to)789-795
Number of pages7
JournalCurrent Eye Research
Volume42
Issue number5
DOIs
Publication statusPublished - 2017

Keywords

  • Foveal maturation
  • hand-held imaging
  • photoreceptors
  • retinopathy of prematurity
  • spectral domain optical coherence tomography
  • MACULAR EDEMA
  • SD-OCT
  • RETINOPATHY
  • CHILDREN
  • PRETERM
  • KIDROP

Cite this