TY - JOUR
T1 - Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and its Correlation with Visual Acuity in Asian Indian Premature Infants in their First Year of Life
AU - Jayadev, Chaitra
AU - Vinekar, Anand
AU - Mangalesh, Shwetha
AU - Kummelil, Mathew Kurian
AU - Kumar, Anupama Kiran
AU - Kemmanu, Vasudha
AU - Sivakumar, Munusamy
AU - Mahendradas, Padmamalini
AU - Avadhani, Kavitha
AU - Bauer, Noel
AU - Webers, Carroll A. B.
AU - Shetty, Bhujang
PY - 2017
Y1 - 2017
N2 - Purpose: To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants.Methods: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards. The study cohort was divided into three groups based on the corrected age, 3-Results: The mean visual acuity of the three groups was 1.60, 1.63, and 1.23 logMAR, respectively (p <0.001). Visual acuity significantly correlated with all four layers (IRL fusion, ELM, EZ, and OS-RPE in the 3-Conclusions: The study provides insights into our understanding of a premature infant's foveal maturation in the first year. Inner retinal fusion or maturation is the most important event that correlates with better visual acuity throughout the first year. In addition, between 9 and 12 months PMA, the completion of the EZ at the foveal center positively influenced visual acuity. The presence of ROP did not influence development of the layers, but the sample size was small for subgroup analysis.
AB - Purpose: To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants.Methods: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards. The study cohort was divided into three groups based on the corrected age, 3-Results: The mean visual acuity of the three groups was 1.60, 1.63, and 1.23 logMAR, respectively (p <0.001). Visual acuity significantly correlated with all four layers (IRL fusion, ELM, EZ, and OS-RPE in the 3-Conclusions: The study provides insights into our understanding of a premature infant's foveal maturation in the first year. Inner retinal fusion or maturation is the most important event that correlates with better visual acuity throughout the first year. In addition, between 9 and 12 months PMA, the completion of the EZ at the foveal center positively influenced visual acuity. The presence of ROP did not influence development of the layers, but the sample size was small for subgroup analysis.
KW - Foveal maturation
KW - hand-held imaging
KW - photoreceptors
KW - retinopathy of prematurity
KW - spectral domain optical coherence tomography
KW - MACULAR EDEMA
KW - SD-OCT
KW - RETINOPATHY
KW - CHILDREN
KW - PRETERM
KW - KIDROP
U2 - 10.1080/02713683.2016.1236964
DO - 10.1080/02713683.2016.1236964
M3 - Article
C2 - 27854139
SN - 0271-3683
VL - 42
SP - 789
EP - 795
JO - Current Eye Research
JF - Current Eye Research
IS - 5
ER -