Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy

Marko Dragas; Igor Koncar; Dragan Opacic; Nikola Ilic; Zivan Maksimovic; Miroslav Markovic; Marko Ercegovac; Tatjana Simic; Marija Pljesa-Ercegovac; Lazar Davidovic

doi:10.1371/journal.pone.0124067

Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy

Marko Dragas^*, Igor Koncar, Dragan Opacic, Nikola Ilic, Zivan Maksimovic, Miroslav Markovic, Marko Ercegovac, Tatjana Simic, Marija Pljesa-Ercegovac, Lazar Davidovic

^*Corresponding author for this work

Fysiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective To evaluate the changes in serum neuron specific enolase and protein S-100B, after carotid endarterectomy performed using the conventional technique with routine shunting and patch closure, or eversion technique without the use of shunt. Materials and Methods Prospective non-randomized study included 43 patients with severe (> 80%) carotid stenosis undergoing carotid endarterectomy in regional anesthesia. Patients were divided into two groups: conventional endarterectomy with routine use of shunt and Dacron patch (csCEA group) and eversion endarterectomy without the use of shunt (eCEA group). Protein S-100B and NSE concentrations were measured from peripheral blood before carotid clamping, after declamping and 24 hours after surgery. Results Neurologic examination and brain CT findings on the first postoperative day did not differ from preoperative controls in any patients. In csCEA group, NSE concentrations decreased after declamping (P

Original language	English
Article number	e0124067
Journal	PLOS ONE
Volume	10
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0124067
Publication status	Published - 10 Apr 2015

Access to Document

10.1371/journal.pone.0124067Licence: CC BY

Cite this

Dragas, M., Koncar, I., Opacic, D., Ilic, N., Maksimovic, Z., Markovic, M., Ercegovac, M., Simic, T., Pljesa-Ercegovac, M., & Davidovic, L. (2015). Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy. PLOS ONE, 10(4), Article e0124067. https://doi.org/10.1371/journal.pone.0124067

@article{c65bf7f32192498a982d0bf76173d8c9,

title = "Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy",

abstract = "Objective To evaluate the changes in serum neuron specific enolase and protein S-100B, after carotid endarterectomy performed using the conventional technique with routine shunting and patch closure, or eversion technique without the use of shunt. Materials and Methods Prospective non-randomized study included 43 patients with severe (> 80%) carotid stenosis undergoing carotid endarterectomy in regional anesthesia. Patients were divided into two groups: conventional endarterectomy with routine use of shunt and Dacron patch (csCEA group) and eversion endarterectomy without the use of shunt (eCEA group). Protein S-100B and NSE concentrations were measured from peripheral blood before carotid clamping, after declamping and 24 hours after surgery. Results Neurologic examination and brain CT findings on the first postoperative day did not differ from preoperative controls in any patients. In csCEA group, NSE concentrations decreased after declamping (P",

author = "Marko Dragas and Igor Koncar and Dragan Opacic and Nikola Ilic and Zivan Maksimovic and Miroslav Markovic and Marko Ercegovac and Tatjana Simic and Marija Pljesa-Ercegovac and Lazar Davidovic",

year = "2015",

month = apr,

day = "10",

doi = "10.1371/journal.pone.0124067",

language = "English",

volume = "10",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

}

TY - JOUR

T1 - Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy

AU - Dragas, Marko

AU - Koncar, Igor

AU - Opacic, Dragan

AU - Ilic, Nikola

AU - Maksimovic, Zivan

AU - Markovic, Miroslav

AU - Ercegovac, Marko

AU - Simic, Tatjana

AU - Pljesa-Ercegovac, Marija

AU - Davidovic, Lazar

PY - 2015/4/10

Y1 - 2015/4/10

N2 - Objective To evaluate the changes in serum neuron specific enolase and protein S-100B, after carotid endarterectomy performed using the conventional technique with routine shunting and patch closure, or eversion technique without the use of shunt. Materials and Methods Prospective non-randomized study included 43 patients with severe (> 80%) carotid stenosis undergoing carotid endarterectomy in regional anesthesia. Patients were divided into two groups: conventional endarterectomy with routine use of shunt and Dacron patch (csCEA group) and eversion endarterectomy without the use of shunt (eCEA group). Protein S-100B and NSE concentrations were measured from peripheral blood before carotid clamping, after declamping and 24 hours after surgery. Results Neurologic examination and brain CT findings on the first postoperative day did not differ from preoperative controls in any patients. In csCEA group, NSE concentrations decreased after declamping (P

AB - Objective To evaluate the changes in serum neuron specific enolase and protein S-100B, after carotid endarterectomy performed using the conventional technique with routine shunting and patch closure, or eversion technique without the use of shunt. Materials and Methods Prospective non-randomized study included 43 patients with severe (> 80%) carotid stenosis undergoing carotid endarterectomy in regional anesthesia. Patients were divided into two groups: conventional endarterectomy with routine use of shunt and Dacron patch (csCEA group) and eversion endarterectomy without the use of shunt (eCEA group). Protein S-100B and NSE concentrations were measured from peripheral blood before carotid clamping, after declamping and 24 hours after surgery. Results Neurologic examination and brain CT findings on the first postoperative day did not differ from preoperative controls in any patients. In csCEA group, NSE concentrations decreased after declamping (P

U2 - 10.1371/journal.pone.0124067

DO - 10.1371/journal.pone.0124067

M3 - Article

C2 - 25859683

SN - 1932-6203

VL - 10

JO - PLOS ONE

JF - PLOS ONE

IS - 4

M1 - e0124067

ER -