Fluctuations of Serum Neuron Specific Enolase and Protein S-100B Concentrations in Relation to the Use of Shunt during Carotid Endarterectomy

Marko Dragas*, Igor Koncar, Dragan Opacic, Nikola Ilic, Zivan Maksimovic, Miroslav Markovic, Marko Ercegovac, Tatjana Simic, Marija Pljesa-Ercegovac, Lazar Davidovic

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective To evaluate the changes in serum neuron specific enolase and protein S-100B, after carotid endarterectomy performed using the conventional technique with routine shunting and patch closure, or eversion technique without the use of shunt. Materials and Methods Prospective non-randomized study included 43 patients with severe (> 80%) carotid stenosis undergoing carotid endarterectomy in regional anesthesia. Patients were divided into two groups: conventional endarterectomy with routine use of shunt and Dacron patch (csCEA group) and eversion endarterectomy without the use of shunt (eCEA group). Protein S-100B and NSE concentrations were measured from peripheral blood before carotid clamping, after declamping and 24 hours after surgery. Results Neurologic examination and brain CT findings on the first postoperative day did not differ from preoperative controls in any patients. In csCEA group, NSE concentrations decreased after declamping (P
Original languageEnglish
Article numbere0124067
Issue number4
Publication statusPublished - 10 Apr 2015

Cite this