Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations

Eline W. Muilwijk; Bart G. J. Dekkers; Stefanie S. V. Henriet; Paul E. Verweij; Bregje Witjes; Astrid M. L. Oude Lashof; Geert H. Groeneveld; Johannes van der Hoeven; Jan Willem C. Alffenaar; Frans G. M. Russel; Frank van de Veerdonk; Roger J. M. Bruggemann

doi:10.1128/AAC.00915-17

Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations

Eline W. Muilwijk^*, Bart G. J. Dekkers, Stefanie S. V. Henriet, Paul E. Verweij, Bregje Witjes, Astrid M. L. Oude Lashof, Geert H. Groeneveld, Johannes van der Hoeven, Jan Willem C. Alffenaar, Frans G. M. Russel, Frank van de Veerdonk, Roger J. M. Bruggemann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

Original language	English
Article number	e00915-17
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00915-17
Publication status	Published - Sept 2017

Keywords

aspergillosis
drug interactions
exposure
influenza
pharmacokinetics
HUMAN LIVER-MICROSOMES
PHARMACOKINETIC INTERACTIONS
CLINICAL-RELEVANCE
METABOLISM
CYP2C19

Access to Document

10.1128/AAC.00915-17

Cite this

Muilwijk, E. W., Dekkers, B. G. J., Henriet, S. S. V., Verweij, P. E., Witjes, B., Lashof, A. M. L. O., Groeneveld, G. H., van der Hoeven, J., Alffenaar, J. W. C., Russel, F. G. M., van de Veerdonk, F., & Bruggemann, R. J. M. (2017). Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations. Antimicrobial Agents and Chemotherapy, 61(9), Article e00915-17. https://doi.org/10.1128/AAC.00915-17

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abstract = "Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.",

keywords = "aspergillosis, drug interactions, exposure, influenza, pharmacokinetics, HUMAN LIVER-MICROSOMES, PHARMACOKINETIC INTERACTIONS, CLINICAL-RELEVANCE, METABOLISM, CYP2C19",

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AU - Muilwijk, Eline W.

AU - Dekkers, Bart G. J.

AU - Henriet, Stefanie S. V.

AU - Verweij, Paul E.

AU - Witjes, Bregje

AU - Lashof, Astrid M. L. Oude

AU - Groeneveld, Geert H.

AU - van der Hoeven, Johannes

AU - Alffenaar, Jan Willem C.

AU - Russel, Frans G. M.

AU - van de Veerdonk, Frank

AU - Bruggemann, Roger J. M.

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AB - Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

KW - aspergillosis

KW - drug interactions

KW - exposure

KW - influenza

KW - pharmacokinetics

KW - HUMAN LIVER-MICROSOMES

KW - PHARMACOKINETIC INTERACTIONS

KW - CLINICAL-RELEVANCE

KW - METABOLISM

KW - CYP2C19

U2 - 10.1128/AAC.00915-17

DO - 10.1128/AAC.00915-17

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JO - Antimicrobial Agents and Chemotherapy

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