Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study

Katherine M. Livingstone; Carlos Celis-Morales; Santiago Navas-Carretero; Rodrigo San-Cristobal; Hannah Forster; Clare B. O'Donovan; Clara Woolhead; Cyril F. M. Marsaux; Anna L. Macready; Rosalind Fallaize; Silvia Kolossa; Lydia Tsirigoti; Christina P. Lambrinou; George Moschonis; Magdalena Godlewska; Agnieszka Surwillo; Christian A. Drevon; Yannis Manios; Iwona Traczyk; Eileen R. Gibney; Lorraine Brennan; Marianne C. Walsh; Julie A. Lovegrove; J. Alfredo Martinez; Wim H. M. Saris; Hannelore Daniel; Mike Gibney; John C. Mathers

doi:10.1017/S0007114515004675

Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study

Katherine M. Livingstone, Carlos Celis-Morales, Santiago Navas-Carretero, Rodrigo San-Cristobal, Hannah Forster, Clare B. O'Donovan, Clara Woolhead, Cyril F. M. Marsaux, Anna L. Macready, Rosalind Fallaize, Silvia Kolossa, Lydia Tsirigoti, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Christian A. Drevon, Yannis Manios, Iwona Traczyk, Eileen R. GibneyLorraine Brennan, Marianne C. Walsh, Julie A. Lovegrove, J. Alfredo Martinez, Wim H. M. Saris, Hannelore Daniel, Mike Gibney, John C. Mathers^*

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Web of Science)

Abstract

The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1.4 cm; P=0.003) and BMI (+0.9 kg/m2; P=0.001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1.4 kg/m2 greater BMI (P trend=0.028) and 3.1 cm greater WC (P trend=0.045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.

Original language	English
Pages (from-to)	440-448
Number of pages	9
Journal	British Journal of Nutrition
Volume	115
Issue number	3
DOIs	https://doi.org/10.1017/S0007114515004675
Publication status	Published - 14 Feb 2016

Keywords

Fat mass- and obesity-associated gene
BMI
Fried foods
Dietary intakes
FTO GENE
RS9939609
RISK
ENERGY-INTAKE
VARIANT
BODY-WEIGHT
WEIGHT-LOSS DIETS
INSULIN-RESISTANCE
INDEX
CONSUMPTION

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10.1017/S0007114515004675

Cite this

Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R., Forster, H., O'Donovan, C. B., Woolhead, C., Marsaux, C. F. M., Macready, A. L., Fallaize, R., Kolossa, S., Tsirigoti, L., Lambrinou, C. P., Moschonis, G., Godlewska, M., Surwillo, A., Drevon, C. A., Manios, Y., Traczyk, I., ... Mathers, J. C. (2016). Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study. British Journal of Nutrition, 115(3), 440-448. https://doi.org/10.1017/S0007114515004675

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title = "Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study",

abstract = "The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1.4 cm; P=0.003) and BMI (+0.9 kg/m2; P=0.001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1.4 kg/m2 greater BMI (P trend=0.028) and 3.1 cm greater WC (P trend=0.045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.",

keywords = "Fat mass- and obesity-associated gene, BMI, Fried foods, Dietary intakes, FTO GENE, RS9939609, RISK, ENERGY-INTAKE, VARIANT, BODY-WEIGHT, WEIGHT-LOSS DIETS, INSULIN-RESISTANCE, INDEX, CONSUMPTION",

author = "Livingstone, {Katherine M.} and Carlos Celis-Morales and Santiago Navas-Carretero and Rodrigo San-Cristobal and Hannah Forster and O'Donovan, {Clare B.} and Clara Woolhead and Marsaux, {Cyril F. M.} and Macready, {Anna L.} and Rosalind Fallaize and Silvia Kolossa and Lydia Tsirigoti and Lambrinou, {Christina P.} and George Moschonis and Magdalena Godlewska and Agnieszka Surwillo and Drevon, {Christian A.} and Yannis Manios and Iwona Traczyk and Gibney, {Eileen R.} and Lorraine Brennan and Walsh, {Marianne C.} and Lovegrove, {Julie A.} and {Alfredo Martinez}, J. and Saris, {Wim H. M.} and Hannelore Daniel and Mike Gibney and Mathers, {John C.}",

year = "2016",

month = feb,

day = "14",

doi = "10.1017/S0007114515004675",

language = "English",

volume = "115",

pages = "440--448",

journal = "British Journal of Nutrition",

issn = "0007-1145",

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Livingstone, KM, Celis-Morales, C, Navas-Carretero, S, San-Cristobal, R, Forster, H, O'Donovan, CB, Woolhead, C, Marsaux, CFM, Macready, AL, Fallaize, R, Kolossa, S, Tsirigoti, L, Lambrinou, CP, Moschonis, G, Godlewska, M, Surwillo, A, Drevon, CA, Manios, Y, Traczyk, I, Gibney, ER, Brennan, L, Walsh, MC, Lovegrove, JA, Alfredo Martinez, J, Saris, WHM, Daniel, H, Gibney, M & Mathers, JC 2016, 'Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study', British Journal of Nutrition, vol. 115, no. 3, pp. 440-448. https://doi.org/10.1017/S0007114515004675

TY - JOUR

T1 - Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study

AU - Livingstone, Katherine M.

AU - Celis-Morales, Carlos

AU - Navas-Carretero, Santiago

AU - San-Cristobal, Rodrigo

AU - Forster, Hannah

AU - O'Donovan, Clare B.

AU - Woolhead, Clara

AU - Marsaux, Cyril F. M.

AU - Macready, Anna L.

AU - Fallaize, Rosalind

AU - Kolossa, Silvia

AU - Tsirigoti, Lydia

AU - Lambrinou, Christina P.

AU - Moschonis, George

AU - Godlewska, Magdalena

AU - Surwillo, Agnieszka

AU - Drevon, Christian A.

AU - Manios, Yannis

AU - Traczyk, Iwona

AU - Gibney, Eileen R.

AU - Brennan, Lorraine

AU - Walsh, Marianne C.

AU - Lovegrove, Julie A.

AU - Alfredo Martinez, J.

AU - Saris, Wim H. M.

AU - Daniel, Hannelore

AU - Gibney, Mike

AU - Mathers, John C.

PY - 2016/2/14

Y1 - 2016/2/14

N2 - The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1.4 cm; P=0.003) and BMI (+0.9 kg/m2; P=0.001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1.4 kg/m2 greater BMI (P trend=0.028) and 3.1 cm greater WC (P trend=0.045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.

AB - The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1.4 cm; P=0.003) and BMI (+0.9 kg/m2; P=0.001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1.4 kg/m2 greater BMI (P trend=0.028) and 3.1 cm greater WC (P trend=0.045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.

KW - Fat mass- and obesity-associated gene

KW - BMI

KW - Fried foods

KW - Dietary intakes

KW - FTO GENE

KW - RS9939609

KW - RISK

KW - ENERGY-INTAKE

KW - VARIANT

KW - BODY-WEIGHT

KW - WEIGHT-LOSS DIETS

KW - INSULIN-RESISTANCE

KW - INDEX

KW - CONSUMPTION

U2 - 10.1017/S0007114515004675

DO - 10.1017/S0007114515004675

M3 - Article

C2 - 26620191

VL - 115

SP - 440

EP - 448

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 3

ER -