Factors associated with Prolonged Inaction in the hypoglycaemic treatment in people with non-insulin dependent Type 2 Diabetes and elevated glycated haemoglobin: A registry-based cohort study

Geert Goderis*, Bert Vaes, Marjan Van den Akker, Steven Elli, Chantal Mathieu, Frank Buntinx, Severine Henrard

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Aims: To assess factors associated with Prolonged Inaction (PI) in insulin-naive patients with Type 2 Diabetes Mellitus (T2DM). PI was defined as the absence of treatment initiation or intensification for >= 12 months despite HbA1c >7% (53 mmol/mol).

Methods: A retrospective cohort study was conducted based on data from Intego, a Flemish General Practice registry. The study period ranged from January 1, 2006 to December 31, 2013. Patients with insulin therapy before the start of the study period were excluded from the analysis. A mixed effects logistic regression was used to assess the association of PI with the presence of co-morbidities, co-medications, process parameters and bio-clinical parameters.

Results: In a population of 2265 patients with T2DM, 578 insulin-naive patients presented with an HbA1c >7% (53 mmol/mol) for >= 12 months. Median follow-up was 1.2 years, median age 67 years, 55% were male. PI was present in 340 patients (59%) and associated with moderate to severe Chronic Kidney Disease, absence of a mental health disorder, less frequent HbA1c measurements, lower HbA1c values and a smaller number of co-medications.

Conclusions: PI is highly prevalent in primary care, particularly in patients with less complex disease status and with less intensive follow-up. (C) 2017 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalPrimary Care Diabetes
Issue number5
Publication statusPublished - Oct 2017


  • Type 2 Diabetes Mellitus
  • Clinical Inertia
  • Oral anti-diabetic treatment
  • Retrospective cohort study

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