Exercise-induced improvements in glucose effectiveness areblunted by a high glycemic diet in adults with prediabetes

Adithya Hari; Ciaran Fealy; Thomas P. J. Solomon; Jacob M. Haus; Karen R. Kelly; Hope Barkoukis; John P. Kirwan

doi:10.1007/s00592-018-1272-2

Exercise-induced improvements in glucose effectiveness areblunted by a high glycemic diet in adults with prediabetes

Adithya Hari, Ciaran Fealy, Thomas P. J. Solomon, Jacob M. Haus, Karen R. Kelly, Hope Barkoukis, John P. Kirwan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AimsGlucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glycemic index of diets, interact with exercise-induced improvements in GE in at-risk populations.MethodsWe enrolled 33 adults with obesity and pre-diabetes (17 males, 65.74.3 years, 34.94.2kgm(-2)) into a 12-week exercise training program (1 hday(-1) and 5 dayweek(-1) at 85% of maximum heart rate) while being randomized to concurrently receive either a low (EX-LOG: 40 +/- 0.3au) or high (EX-HIG: 80 +/- 0.6au) glycemic index diet. A 75-g oral-glucose-tolerance test (OGTT) was performed before and after the intervention and GE was calculated using the Nagasaka equation. Insulin resistance was estimated using a hyperinsulinemic-euglycemic clamp and cardiorespiratory fitness using a VO2max test.Results: Both EX-LOG and EX-HIG groups had similar improvements in weight (8.6 +/- 5.1kg, P0.05) and increased by 20% post-intervention in the EX-LOG arm (GE: 0.07-0.57mgdL(-1)min(-1), P

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Acta Diabetologica
Volume	56
Issue number	2
DOIs	https://doi.org/10.1007/s00592-018-1272-2
Publication status	Published - Feb 2019

Keywords

Aerobic exercise training
Glycemic index
Diet
Glucose effectiveness
Hyperinsulinemic-euglycemic clamp
Prediabetes
INSULIN-RESISTANCE
DISPOSITION INDEX
TOLERANCE
SENSITIVITY
OBESE
SECRETION

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10.1007/s00592-018-1272-2

Cite this

@article{40c03d8e51a349cbab4b7a0e226267b6,

title = "Exercise-induced improvements in glucose effectiveness areblunted by a high glycemic diet in adults with prediabetes",

abstract = "AimsGlucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glycemic index of diets, interact with exercise-induced improvements in GE in at-risk populations.MethodsWe enrolled 33 adults with obesity and pre-diabetes (17 males, 65.74.3 years, 34.94.2kgm(-2)) into a 12-week exercise training program (1 hday(-1) and 5 dayweek(-1) at 85% of maximum heart rate) while being randomized to concurrently receive either a low (EX-LOG: 40 +/- 0.3au) or high (EX-HIG: 80 +/- 0.6au) glycemic index diet. A 75-g oral-glucose-tolerance test (OGTT) was performed before and after the intervention and GE was calculated using the Nagasaka equation. Insulin resistance was estimated using a hyperinsulinemic-euglycemic clamp and cardiorespiratory fitness using a VO2max test.Results: Both EX-LOG and EX-HIG groups had similar improvements in weight (8.6 +/- 5.1kg, P0.05) and increased by 20% post-intervention in the EX-LOG arm (GE: 0.07-0.57mgdL(-1)min(-1), P",

keywords = "Aerobic exercise training, Glycemic index, Diet, Glucose effectiveness, Hyperinsulinemic-euglycemic clamp, Prediabetes, INSULIN-RESISTANCE, DISPOSITION INDEX, TOLERANCE, SENSITIVITY, OBESE, SECRETION",

author = "Adithya Hari and Ciaran Fealy and Solomon, {Thomas P. J.} and Haus, {Jacob M.} and Kelly, {Karen R.} and Hope Barkoukis and Kirwan, {John P.}",

note = "Funding Information: Funding Supported by the National Institutes of Health (NIH) (Grants RO1 AG12834; to JPK) and the NIH National Center for Research Resources (Cleveland, OH, USA) (Clinical and Translational Science Award 1UL1RR024989). Funding Information: We thank the research volunteers for their outstanding dedication and effort and the nursing staff of the Clinical Research Unit and the staff and students who helped with the implementation of the study and assisted with data collection. We also thank the dietary staff in the Bionutrition Unit of the CTSC for their assistance with preparing meals for this study. We thank the study participants who volunteered for this study and the nurses and staff of the Cleveland Clinic Clinical Research Unit for their invaluable assistance with data collection. Publisher Copyright: {\textcopyright} 2019, Springer-Verlag Italia S.r.l., part of Springer Nature.",

year = "2019",

month = feb,

doi = "10.1007/s00592-018-1272-2",

language = "English",

volume = "56",

pages = "211--217",

journal = "Acta Diabetologica",

issn = "0940-5429",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Exercise-induced improvements in glucose effectiveness areblunted by a high glycemic diet in adults with prediabetes

AU - Hari, Adithya

AU - Fealy, Ciaran

AU - Solomon, Thomas P. J.

AU - Haus, Jacob M.

AU - Kelly, Karen R.

AU - Barkoukis, Hope

AU - Kirwan, John P.

N1 - Funding Information: Funding Supported by the National Institutes of Health (NIH) (Grants RO1 AG12834; to JPK) and the NIH National Center for Research Resources (Cleveland, OH, USA) (Clinical and Translational Science Award 1UL1RR024989). Funding Information: We thank the research volunteers for their outstanding dedication and effort and the nursing staff of the Clinical Research Unit and the staff and students who helped with the implementation of the study and assisted with data collection. We also thank the dietary staff in the Bionutrition Unit of the CTSC for their assistance with preparing meals for this study. We thank the study participants who volunteered for this study and the nurses and staff of the Cleveland Clinic Clinical Research Unit for their invaluable assistance with data collection. Publisher Copyright: © 2019, Springer-Verlag Italia S.r.l., part of Springer Nature.

PY - 2019/2

Y1 - 2019/2

N2 - AimsGlucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glycemic index of diets, interact with exercise-induced improvements in GE in at-risk populations.MethodsWe enrolled 33 adults with obesity and pre-diabetes (17 males, 65.74.3 years, 34.94.2kgm(-2)) into a 12-week exercise training program (1 hday(-1) and 5 dayweek(-1) at 85% of maximum heart rate) while being randomized to concurrently receive either a low (EX-LOG: 40 +/- 0.3au) or high (EX-HIG: 80 +/- 0.6au) glycemic index diet. A 75-g oral-glucose-tolerance test (OGTT) was performed before and after the intervention and GE was calculated using the Nagasaka equation. Insulin resistance was estimated using a hyperinsulinemic-euglycemic clamp and cardiorespiratory fitness using a VO2max test.Results: Both EX-LOG and EX-HIG groups had similar improvements in weight (8.6 +/- 5.1kg, P0.05) and increased by 20% post-intervention in the EX-LOG arm (GE: 0.07-0.57mgdL(-1)min(-1), P

AB - AimsGlucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glycemic index of diets, interact with exercise-induced improvements in GE in at-risk populations.MethodsWe enrolled 33 adults with obesity and pre-diabetes (17 males, 65.74.3 years, 34.94.2kgm(-2)) into a 12-week exercise training program (1 hday(-1) and 5 dayweek(-1) at 85% of maximum heart rate) while being randomized to concurrently receive either a low (EX-LOG: 40 +/- 0.3au) or high (EX-HIG: 80 +/- 0.6au) glycemic index diet. A 75-g oral-glucose-tolerance test (OGTT) was performed before and after the intervention and GE was calculated using the Nagasaka equation. Insulin resistance was estimated using a hyperinsulinemic-euglycemic clamp and cardiorespiratory fitness using a VO2max test.Results: Both EX-LOG and EX-HIG groups had similar improvements in weight (8.6 +/- 5.1kg, P0.05) and increased by 20% post-intervention in the EX-LOG arm (GE: 0.07-0.57mgdL(-1)min(-1), P

KW - Aerobic exercise training

KW - Glycemic index

KW - Diet

KW - Glucose effectiveness

KW - Hyperinsulinemic-euglycemic clamp

KW - Prediabetes

KW - INSULIN-RESISTANCE

KW - DISPOSITION INDEX

KW - TOLERANCE

KW - SENSITIVITY

KW - OBESE

KW - SECRETION

U2 - 10.1007/s00592-018-1272-2

DO - 10.1007/s00592-018-1272-2

M3 - Article

C2 - 30612202

SN - 0940-5429

VL - 56

SP - 211

EP - 217

JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 2

ER -