TY - JOUR
T1 - Evaluation of a 5 day accelerated 1 Hz repetitive transcranial magnetic stimulation protocol in major depression
T2 - A feasibility study
AU - Miron, Jean Philippe
AU - Hyde, Molly
AU - Fox, Linsay
AU - Sheen, Jack
AU - Voetterl, Helena
AU - Mansouri, Farrokh
AU - Desbeaumes Jodoin, Véronique
AU - Zhou, Ryan
AU - Dees, Sinjin
AU - Mir-Moghtadaei, Arsalan
AU - Blumberger, Daniel M.
AU - Daskalakis, Zafiris J.
AU - Vila-Rodriguez, Fidel
AU - Downar, Jonathan
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD) but requires daily travel to a treatment clinic over several weeks. Shorter rTMS courses retaining similar effectiveness would thus increase the practicality and scalability of the technique, and therefore its accessibility. Objective: We assessed the feasibility of a novel 5 day accelerated 1 Hz rTMS protocol. We hypothesized that this novel rTMS protocol would be safe and well-tolerated while shortening the overall treatment course. Methods: We conducted a prospective, single-arm, open-label feasibility study. Thirty (30) participants received a one-week (5 days) accelerated (8 sessions per day, 40 sessions total) course of 1 Hz rTMS (600 pulses per session, 50-minute intersession interval) over the right dorsolateral prefrontal cortex (R-DLPFC) using a figure-of-eight coil at 120% of the resting motor threshold (rMT). Primary outcomes were response and remission rates on the Beck Depression Inventory-II (BDI-II). Results: Response and remission rates 1 week after treatment were 33.3% and 13.3% respectively and increased to 43.3% and 30.0% at follow-up 4 weeks after treatment. No serious adverse events occurred. All participants reported manageable pain levels. Conclusion: 1 Hz rTMS administered 8 times daily for 5 days is safe and well-tolerated. Validation in a randomized trial will be required.
AB - Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD) but requires daily travel to a treatment clinic over several weeks. Shorter rTMS courses retaining similar effectiveness would thus increase the practicality and scalability of the technique, and therefore its accessibility. Objective: We assessed the feasibility of a novel 5 day accelerated 1 Hz rTMS protocol. We hypothesized that this novel rTMS protocol would be safe and well-tolerated while shortening the overall treatment course. Methods: We conducted a prospective, single-arm, open-label feasibility study. Thirty (30) participants received a one-week (5 days) accelerated (8 sessions per day, 40 sessions total) course of 1 Hz rTMS (600 pulses per session, 50-minute intersession interval) over the right dorsolateral prefrontal cortex (R-DLPFC) using a figure-of-eight coil at 120% of the resting motor threshold (rMT). Primary outcomes were response and remission rates on the Beck Depression Inventory-II (BDI-II). Results: Response and remission rates 1 week after treatment were 33.3% and 13.3% respectively and increased to 43.3% and 30.0% at follow-up 4 weeks after treatment. No serious adverse events occurred. All participants reported manageable pain levels. Conclusion: 1 Hz rTMS administered 8 times daily for 5 days is safe and well-tolerated. Validation in a randomized trial will be required.
KW - arTMS
KW - LF
KW - low-frequency
KW - rTMS
KW - TMS
U2 - 10.1016/j.jadr.2021.100077
DO - 10.1016/j.jadr.2021.100077
M3 - Article
SN - 2666-9153
VL - 4
JO - Journal of Affective Disorders Reports
JF - Journal of Affective Disorders Reports
M1 - 100077
ER -