Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Ines Lujambio, Mariana Sottolano, Leonella Luzardo, Sebastin Robaina, Nadia Krul, L. Thijs, Florencia Carusso, Alicia da Rosa, Ana C. Rios, Alicia Olascoaga, M. Garau, L. Gadola, Oscar Noboa, Jan Staessen, Jose Boggia

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Abstract

Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR <60 versus ?60?mL/min/1.73?m(2)) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6?mL/min/1.73?m(2) higher (P <0.0001) than eGFRcys. The prevalence of eGFR
Original languageEnglish
Article number837106
JournalInternational Journal of Nephrology
Volume2014
DOIs
Publication statusPublished - 2014

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