Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Ines Lujambio; Mariana Sottolano; Leonella Luzardo; Sebastin Robaina; Nadia Krul; L. Thijs; Florencia Carusso; Alicia da Rosa; Ana C. Rios; Alicia Olascoaga; M. Garau; L. Gadola; Oscar Noboa; Jan Staessen; Jose Boggia

doi:10.1155/2014/837106

Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Ines Lujambio, Mariana Sottolano, Leonella Luzardo, Sebastin Robaina, Nadia Krul, L. Thijs, Florencia Carusso, Alicia da Rosa, Ana C. Rios, Alicia Olascoaga, M. Garau, L. Gadola, Oscar Noboa, Jan Staessen, Jose Boggia^*

^*Corresponding author for this work

Epidemiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR <60 versus ?60?mL/min/1.73?m(2)) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6?mL/min/1.73?m(2) higher (P <0.0001) than eGFRcys. The prevalence of eGFR

Original language	English
Article number	837106
Journal	International Journal of Nephrology
Volume	2014
DOIs	https://doi.org/10.1155/2014/837106
Publication status	Published - 2014

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10.1155/2014/837106Licence: CC BY

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Lujambio, I., Sottolano, M., Luzardo, L., Robaina, S., Krul, N., Thijs, L., Carusso, F., da Rosa, A., Rios, A. C., Olascoaga, A., Garau, M., Gadola, L., Noboa, O., Staessen, J., & Boggia, J. (2014). Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population. International Journal of Nephrology, 2014, Article 837106. https://doi.org/10.1155/2014/837106

@article{a068a7a5811d4cb394852881ca04b002,

title = "Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population",

abstract = "Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR <60 versus ?60?mL/min/1.73?m(2)) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6?mL/min/1.73?m(2) higher (P <0.0001) than eGFRcys. The prevalence of eGFR ",

author = "Ines Lujambio and Mariana Sottolano and Leonella Luzardo and Sebastin Robaina and Nadia Krul and L. Thijs and Florencia Carusso and {da Rosa}, Alicia and Rios, {Ana C.} and Alicia Olascoaga and M. Garau and L. Gadola and Oscar Noboa and Jan Staessen and Jose Boggia",

year = "2014",

doi = "10.1155/2014/837106",

language = "English",

volume = "2014",

journal = "International Journal of Nephrology",

issn = "2090-2158",

publisher = "Hindawi Publishing Corporation",

}

Lujambio, I, Sottolano, M, Luzardo, L, Robaina, S, Krul, N, Thijs, L, Carusso, F, da Rosa, A, Rios, AC, Olascoaga, A, Garau, M, Gadola, L, Noboa, O, Staessen, J & Boggia, J 2014, 'Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population', International Journal of Nephrology, vol. 2014, 837106. https://doi.org/10.1155/2014/837106

TY - JOUR

T1 - Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

AU - Lujambio, Ines

AU - Sottolano, Mariana

AU - Luzardo, Leonella

AU - Robaina, Sebastin

AU - Krul, Nadia

AU - Thijs, L.

AU - Carusso, Florencia

AU - da Rosa, Alicia

AU - Rios, Ana C.

AU - Olascoaga, Alicia

AU - Garau, M.

AU - Gadola, L.

AU - Noboa, Oscar

AU - Staessen, Jan

AU - Boggia, Jose

PY - 2014

Y1 - 2014

N2 - Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR <60 versus ?60?mL/min/1.73?m(2)) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6?mL/min/1.73?m(2) higher (P <0.0001) than eGFRcys. The prevalence of eGFR

AB - Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR <60 versus ?60?mL/min/1.73?m(2)) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6?mL/min/1.73?m(2) higher (P <0.0001) than eGFRcys. The prevalence of eGFR

U2 - 10.1155/2014/837106

DO - 10.1155/2014/837106

M3 - Article

C2 - 25215234

SN - 2090-2158

VL - 2014

JO - International Journal of Nephrology

JF - International Journal of Nephrology

M1 - 837106

ER -